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• W2035966078 startingPage "677" @default.
• W2035966078 abstract "An expression system that utilized yeast copper metallothionine promoter and ubiquitin fusion technology to express the human estrogen receptor gene in yeast is described. We have studied the biochemical and transcriptional regulatory properties of the human estrogen receptor. The biochemical properties of the yeast expressed receptors are identical to the receptors isolated from human tissue. Estradiol mediated activation of transcription by the receptor was studied by a reporter β-galactosidase gene where expression was under the control of estrogen response elements. Using this expression system and a hyperpermeable yeast strain we have studied the effects of various antiestrogens on the regulation of estrogen receptor function. We demonstrate that tamoxifen and ICI 164,384 are capable of binding to the receptor but neither antiestrogen was able to block the estradiol mediated increase in transcription. In fact, both antiestrogens exerted weak agonist activity in this system." @default.
• W2035966078 created "2016-06-24" @default.
• W2035966078 creator A5015336616 @default.
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• W2035966078 date "1992-08-01" @default.
• W2035966078 modified "2023-10-11" @default.
• W2035966078 title "Human estrogen receptor regulation in a yeast model system and studies on receptor agonists and antagonists" @default.
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• W2035966078 doi "https://doi.org/10.1016/0960-0760(92)90108-u" @default.
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