FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035967874> ?p ?o ?g. }

• W2035967874 endingPage "379" @default.
• W2035967874 startingPage "368" @default.
• W2035967874 abstract "Abstract Openers of neuronal voltage‐gated potassium channels (K V ) are of interest as therapeutic agents for treating pain (flupirtine) and epilepsy (retigabine). In an effort to better understand the mechanisms of action and toxicity of flupirtine, we synthesized nine novel analogues with varying redox behavior. Flupirtine can be oxidatively metabolized into azaquinone diimines; thus, the oxidation potentials of flupirtine and its analogues were measured by cyclic voltammetry. K V 7.2/3 (KCNQ2/3) opening activity was determined by an established assay with HEK293 cells overexpressing these channels. A link was found between the oxidation potentials of the compounds and their EC 50 values for potassium channel opening activity. On the other hand, no correlation was observed between oxidation potentials and cytotoxicity in cultures of transgenic mouse hepatocytes (TAMH). These results support the idea that oxidative metabolites of flupirtine contribute to the mechanism of action, similar to what was recently proposed for acetaminophen (paracetamol), but not to hepatotoxicity." @default.
• W2035967874 created "2016-06-24" @default.
• W2035967874 creator A5045541032 @default.
• W2035967874 creator A5057595553 @default.
• W2035967874 creator A5077715708 @default.
• W2035967874 creator A5080688815 @default.
• W2035967874 creator A5085557911 @default.
• W2035967874 date "2014-11-12" @default.
• W2035967874 modified "2023-10-16" @default.
• W2035967874 title "Oxidation Potentials of N-Modified Derivatives of the Analgesic Flupirtine Linked to Potassium K_V7 Channel Opening Activity But Not Hepatocyte Toxicity" @default.
• W2035967874 cites W1561826938 @default.
• W2035967874 cites W1973696941 @default.
• W2035967874 cites W1979388641 @default.
• W2035967874 cites W1980691830 @default.
• W2035967874 cites W1988252969 @default.
• W2035967874 cites W2009134867 @default.
• W2035967874 cites W2009246906 @default.
• W2035967874 cites W2010278844 @default.
• W2035967874 cites W2013702972 @default.
• W2035967874 cites W2017693139 @default.
• W2035967874 cites W2019959711 @default.
• W2035967874 cites W2021704663 @default.
• W2035967874 cites W2041367643 @default.
• W2035967874 cites W2042725396 @default.
• W2035967874 cites W2051476546 @default.
• W2035967874 cites W2053378761 @default.
• W2035967874 cites W2061202162 @default.
• W2035967874 cites W2062805466 @default.
• W2035967874 cites W2070671425 @default.
• W2035967874 cites W2071867698 @default.
• W2035967874 cites W2080843764 @default.
• W2035967874 cites W2083213202 @default.
• W2035967874 cites W2092170600 @default.
• W2035967874 cites W2127853318 @default.
• W2035967874 cites W2144420181 @default.
• W2035967874 cites W2155868478 @default.
• W2035967874 cites W2163335277 @default.
• W2035967874 cites W2168858520 @default.
• W2035967874 cites W2169958072 @default.
• W2035967874 cites W2820209543 @default.
• W2035967874 doi "https://doi.org/10.1002/cmdc.201402442" @default.
• W2035967874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25392984" @default.
• W2035967874 hasPublicationYear "2014" @default.
• W2035967874 type Work @default.
• W2035967874 sameAs 2035967874 @default.
• W2035967874 citedByCount "15" @default.
• W2035967874 countsByYear W20359678742016 @default.
• W2035967874 countsByYear W20359678742017 @default.
• W2035967874 countsByYear W20359678742018 @default.
• W2035967874 countsByYear W20359678742019 @default.
• W2035967874 countsByYear W20359678742020 @default.
• W2035967874 countsByYear W20359678742021 @default.
• W2035967874 countsByYear W20359678742022 @default.
• W2035967874 countsByYear W20359678742023 @default.
• W2035967874 crossrefType "journal-article" @default.
• W2035967874 hasAuthorship W2035967874A5045541032 @default.
• W2035967874 hasAuthorship W2035967874A5057595553 @default.
• W2035967874 hasAuthorship W2035967874A5077715708 @default.
• W2035967874 hasAuthorship W2035967874A5080688815 @default.
• W2035967874 hasAuthorship W2035967874A5085557911 @default.
• W2035967874 hasConcept C12554922 @default.
• W2035967874 hasConcept C147789679 @default.
• W2035967874 hasConcept C17525397 @default.
• W2035967874 hasConcept C178790620 @default.
• W2035967874 hasConcept C185592680 @default.
• W2035967874 hasConcept C202751555 @default.
• W2035967874 hasConcept C21951064 @default.
• W2035967874 hasConcept C2776120743 @default.
• W2035967874 hasConcept C2777869211 @default.
• W2035967874 hasConcept C2778722691 @default.
• W2035967874 hasConcept C2779491297 @default.
• W2035967874 hasConcept C2780820201 @default.
• W2035967874 hasConcept C29730261 @default.
• W2035967874 hasConcept C517785266 @default.
• W2035967874 hasConcept C52859227 @default.
• W2035967874 hasConcept C55493867 @default.
• W2035967874 hasConcept C55904794 @default.
• W2035967874 hasConcept C71924100 @default.
• W2035967874 hasConcept C83743174 @default.
• W2035967874 hasConcept C86803240 @default.
• W2035967874 hasConcept C98274493 @default.
• W2035967874 hasConceptScore W2035967874C12554922 @default.
• W2035967874 hasConceptScore W2035967874C147789679 @default.
• W2035967874 hasConceptScore W2035967874C17525397 @default.
• W2035967874 hasConceptScore W2035967874C178790620 @default.
• W2035967874 hasConceptScore W2035967874C185592680 @default.
• W2035967874 hasConceptScore W2035967874C202751555 @default.
• W2035967874 hasConceptScore W2035967874C21951064 @default.
• W2035967874 hasConceptScore W2035967874C2776120743 @default.
• W2035967874 hasConceptScore W2035967874C2777869211 @default.
• W2035967874 hasConceptScore W2035967874C2778722691 @default.
• W2035967874 hasConceptScore W2035967874C2779491297 @default.
• W2035967874 hasConceptScore W2035967874C2780820201 @default.
• W2035967874 hasConceptScore W2035967874C29730261 @default.
• W2035967874 hasConceptScore W2035967874C517785266 @default.
• W2035967874 hasConceptScore W2035967874C52859227 @default.
• W2035967874 hasConceptScore W2035967874C55493867 @default.
• W2035967874 hasConceptScore W2035967874C55904794 @default.

• next