FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035973771> ?p ?o ?g. }

• W2035973771 endingPage "376" @default.
• W2035973771 startingPage "368" @default.
• W2035973771 abstract "Metam sodium (MS) is a soil fumigant and Category II pesticide with a relatively low toxicity in mammals. Previous data have shown an ability to impair reproductive mechanisms in ovariectomized, estradiol-primed rats. A single i.p. injection blocked the luteinizing hormone (LH) surge that in gonadal-intact females initiates the final stages of follicular and oocytic maturation and serves as the trigger for ovulation. The effect paralleled a fall in hypothalamic norepinephrine (NE) and rise in hypothalamic dopamine (DA) that was likely due to a suppression in dopamine-beta-hydroxylase activity. In addition to determining the influence on catecholamine (CA) concentrations from a single oral exposure to MS, the present study explored effects of longer, 3-week treatments on estrous cyclicity, the LH surge, ovulation and hypothalamic CAs. Normally cycling 90 d S-D rats were administered MS (0-200 mg/kg/d, oral) and cyclicity was monitored daily. At the end of the 3rd week, proestrous blood was sampled over the afternoon from regular 4-day cyclers for a determination of LH. These animals were then killed on the following day of estrus (treatment days 21-26) for oocyte retrieval and assessment of hypothalamic CAs. Results showed that shortly after treatment began there occurred a dose-related period of persistent diestrus that typically lasted 8-16 d before regular cycles were reinstated. After 3 weeks, no effects were seen on the magnitude/timing of the LH surge or ovulated oocyte numbers. Anterior and posterior hypothalamic NE and DA were not significantly different from controls, although DA turnover (reflected by the ratio of DOPAC {3,4-dihydroxy-phenylacetic acid} to DA) in both anterior hypothalamic and caudate regions was decreased at all dosages. The data indicate that a 3 week oral exposure to MS induced an initial period of extended diestrus before the resumption of apparently normal reproductive activity, with previously reported CA alterations (apart from a persistent alteration in the DOPAC/DA ratio) being normalized by the end of dosing." @default.
• W2035973771 created "2016-06-24" @default.
• W2035973771 creator A5006697263 @default.
• W2035973771 creator A5044289804 @default.
• W2035973771 creator A5079794491 @default.
• W2035973771 date "2007-05-01" @default.
• W2035973771 modified "2023-10-02" @default.
• W2035973771 title "Reproductive functions and hypothalamic catecholamines in response to the soil fumigant metam sodium: Adaptations to extended exposures" @default.
• W2035973771 cites W18679281 @default.
• W2035973771 cites W1967476250 @default.
• W2035973771 cites W2019352201 @default.
• W2035973771 cites W2021056125 @default.
• W2035973771 cites W2033940320 @default.
• W2035973771 cites W2052301245 @default.
• W2035973771 cites W2053397414 @default.
• W2035973771 cites W2065258589 @default.
• W2035973771 cites W2073211962 @default.
• W2035973771 cites W2080470864 @default.
• W2035973771 cites W2086227638 @default.
• W2035973771 cites W2098968367 @default.
• W2035973771 cites W2103190550 @default.
• W2035973771 doi "https://doi.org/10.1016/j.ntt.2006.11.011" @default.
• W2035973771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17258889" @default.
• W2035973771 hasPublicationYear "2007" @default.
• W2035973771 type Work @default.
• W2035973771 sameAs 2035973771 @default.
• W2035973771 citedByCount "7" @default.
• W2035973771 countsByYear W20359737712018 @default.
• W2035973771 countsByYear W20359737712021 @default.
• W2035973771 countsByYear W20359737712023 @default.
• W2035973771 crossrefType "journal-article" @default.
• W2035973771 hasAuthorship W2035973771A5006697263 @default.
• W2035973771 hasAuthorship W2035973771A5044289804 @default.
• W2035973771 hasAuthorship W2035973771A5079794491 @default.
• W2035973771 hasConcept C126322002 @default.
• W2035973771 hasConcept C134018914 @default.
• W2035973771 hasConcept C187785154 @default.
• W2035973771 hasConcept C1998276 @default.
• W2035973771 hasConcept C2775894120 @default.
• W2035973771 hasConcept C2777003273 @default.
• W2035973771 hasConcept C2777702977 @default.
• W2035973771 hasConcept C2778575703 @default.
• W2035973771 hasConcept C513476851 @default.
• W2035973771 hasConcept C71315377 @default.
• W2035973771 hasConcept C71924100 @default.
• W2035973771 hasConcept C86803240 @default.
• W2035973771 hasConceptScore W2035973771C126322002 @default.
• W2035973771 hasConceptScore W2035973771C134018914 @default.
• W2035973771 hasConceptScore W2035973771C187785154 @default.
• W2035973771 hasConceptScore W2035973771C1998276 @default.
• W2035973771 hasConceptScore W2035973771C2775894120 @default.
• W2035973771 hasConceptScore W2035973771C2777003273 @default.
• W2035973771 hasConceptScore W2035973771C2777702977 @default.
• W2035973771 hasConceptScore W2035973771C2778575703 @default.
• W2035973771 hasConceptScore W2035973771C513476851 @default.
• W2035973771 hasConceptScore W2035973771C71315377 @default.
• W2035973771 hasConceptScore W2035973771C71924100 @default.
• W2035973771 hasConceptScore W2035973771C86803240 @default.
• W2035973771 hasIssue "3" @default.
• W2035973771 hasLocation W20359737711 @default.
• W2035973771 hasLocation W20359737712 @default.
• W2035973771 hasOpenAccess W2035973771 @default.
• W2035973771 hasPrimaryLocation W20359737711 @default.
• W2035973771 hasRelatedWork W1966283443 @default.
• W2035973771 hasRelatedWork W1977698842 @default.
• W2035973771 hasRelatedWork W1978175539 @default.
• W2035973771 hasRelatedWork W2013275608 @default.
• W2035973771 hasRelatedWork W2034255477 @default.
• W2035973771 hasRelatedWork W2053421360 @default.
• W2035973771 hasRelatedWork W2056116732 @default.
• W2035973771 hasRelatedWork W2062579683 @default.
• W2035973771 hasRelatedWork W2089103608 @default.
• W2035973771 hasRelatedWork W2168709152 @default.
• W2035973771 hasVolume "29" @default.
• W2035973771 isParatext "false" @default.
• W2035973771 isRetracted "false" @default.
• W2035973771 magId "2035973771" @default.
• W2035973771 workType "article" @default.