FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035982783> ?p ?o ?g. }

• W2035982783 endingPage "2963" @default.
• W2035982783 startingPage "2955" @default.
• W2035982783 abstract "Studies were undertaken, using isolated prostatic epithelial and stromal cells, to evaluate the role of basic fibroblast growth factor (bFGF) in the regulation of benign prostatic growth. bFGF was detected in lysates, but not the conditioned media, of cultured prostatic epithelial and stromal cells by Western immunoblotting and immunoprecipitation of metabolically labeled proteins. Immunofluorescence analysis of benign human prostate localized the majority of bFGF to the prostatic stroma. In addition, bFGF was a potent stimulator of stromal cell proliferation in vitro, but was not mitogenic to cultured epithelial cells. Further studies demonstrated bFGF receptors (Kd = 258 pM; 61,400 receptors/cell) on stromal cells, but not epithelial cells. Epithelial cell-conditioned medium was mitogenic for stromal cells, suggesting the presence of paracrine interactions. However, bFGF does not appear to be the mediator of this interaction, since the mitogenic effect of epithelial cell-conditioned medium on stromal cells was not significantly reduced by the addition of anti-bFGF. Additional studies showed that concentrated stromal cell-conditioned medium was not mitogenic to cultured stromal cells under serum-free defined conditions, indicating the lack of an external autocine mechanism. These studies demonstrate that bFGF is actively synthesized by isolated prostatic epithelial and stromal cells, but is largely not secreted. Prostatic stroma, but not epithelia, are responsive to the mitogenic effect of bFGF in vitro. However, because of the limited secretion of bFGF by prostatic cells, the mechanism(s) of bFGF-mediated regulation of stromal growth remains unclear." @default.
• W2035982783 created "2016-06-24" @default.
• W2035982783 creator A5019669673 @default.
• W2035982783 creator A5028649129 @default.
• W2035982783 creator A5030411648 @default.
• W2035982783 creator A5060457090 @default.
• W2035982783 date "1992-05-01" @default.
• W2035982783 modified "2023-10-16" @default.
• W2035982783 title "Basic fibroblast growth factor: a potential mediator of stromal growth in the human prostate." @default.
• W2035982783 cites W1514636046 @default.
• W2035982783 cites W1630869555 @default.
• W2035982783 cites W1948307417 @default.
• W2035982783 cites W1963700367 @default.
• W2035982783 cites W1972855766 @default.
• W2035982783 cites W1976183092 @default.
• W2035982783 cites W1978875825 @default.
• W2035982783 cites W1981237194 @default.
• W2035982783 cites W1984648137 @default.
• W2035982783 cites W1995142571 @default.
• W2035982783 cites W2040202657 @default.
• W2035982783 cites W2048249923 @default.
• W2035982783 cites W2052425221 @default.
• W2035982783 cites W2058525519 @default.
• W2035982783 cites W2064098261 @default.
• W2035982783 cites W2074641624 @default.
• W2035982783 cites W2076432168 @default.
• W2035982783 cites W2090041201 @default.
• W2035982783 cites W2097994844 @default.
• W2035982783 cites W2101108802 @default.
• W2035982783 cites W2111161686 @default.
• W2035982783 cites W2127276219 @default.
• W2035982783 cites W2154652969 @default.
• W2035982783 cites W2163170931 @default.
• W2035982783 cites W2166800133 @default.
• W2035982783 cites W2408309479 @default.
• W2035982783 doi "https://doi.org/10.1210/endo.130.5.1374018" @default.
• W2035982783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1374018" @default.
• W2035982783 hasPublicationYear "1992" @default.
• W2035982783 type Work @default.
• W2035982783 sameAs 2035982783 @default.
• W2035982783 citedByCount "90" @default.
• W2035982783 countsByYear W20359827832015 @default.
• W2035982783 countsByYear W20359827832017 @default.
• W2035982783 countsByYear W20359827832019 @default.
• W2035982783 countsByYear W20359827832021 @default.
• W2035982783 crossrefType "journal-article" @default.
• W2035982783 hasAuthorship W2035982783A5019669673 @default.
• W2035982783 hasAuthorship W2035982783A5028649129 @default.
• W2035982783 hasAuthorship W2035982783A5030411648 @default.
• W2035982783 hasAuthorship W2035982783A5060457090 @default.
• W2035982783 hasConcept C126322002 @default.
• W2035982783 hasConcept C134018914 @default.
• W2035982783 hasConcept C16930146 @default.
• W2035982783 hasConcept C170493617 @default.
• W2035982783 hasConcept C203014093 @default.
• W2035982783 hasConcept C204232928 @default.
• W2035982783 hasConcept C2775960820 @default.
• W2035982783 hasConcept C2777587049 @default.
• W2035982783 hasConcept C2780381497 @default.
• W2035982783 hasConcept C502942594 @default.
• W2035982783 hasConcept C52124034 @default.
• W2035982783 hasConcept C54355233 @default.
• W2035982783 hasConcept C55493867 @default.
• W2035982783 hasConcept C62112901 @default.
• W2035982783 hasConcept C71924100 @default.
• W2035982783 hasConcept C7876069 @default.
• W2035982783 hasConcept C81885089 @default.
• W2035982783 hasConcept C86803240 @default.
• W2035982783 hasConcept C95444343 @default.
• W2035982783 hasConceptScore W2035982783C126322002 @default.
• W2035982783 hasConceptScore W2035982783C134018914 @default.
• W2035982783 hasConceptScore W2035982783C16930146 @default.
• W2035982783 hasConceptScore W2035982783C170493617 @default.
• W2035982783 hasConceptScore W2035982783C203014093 @default.
• W2035982783 hasConceptScore W2035982783C204232928 @default.
• W2035982783 hasConceptScore W2035982783C2775960820 @default.
• W2035982783 hasConceptScore W2035982783C2777587049 @default.
• W2035982783 hasConceptScore W2035982783C2780381497 @default.
• W2035982783 hasConceptScore W2035982783C502942594 @default.
• W2035982783 hasConceptScore W2035982783C52124034 @default.
• W2035982783 hasConceptScore W2035982783C54355233 @default.
• W2035982783 hasConceptScore W2035982783C55493867 @default.
• W2035982783 hasConceptScore W2035982783C62112901 @default.
• W2035982783 hasConceptScore W2035982783C71924100 @default.
• W2035982783 hasConceptScore W2035982783C7876069 @default.
• W2035982783 hasConceptScore W2035982783C81885089 @default.
• W2035982783 hasConceptScore W2035982783C86803240 @default.
• W2035982783 hasConceptScore W2035982783C95444343 @default.
• W2035982783 hasIssue "5" @default.
• W2035982783 hasLocation W20359827831 @default.
• W2035982783 hasLocation W20359827832 @default.
• W2035982783 hasOpenAccess W2035982783 @default.
• W2035982783 hasPrimaryLocation W20359827831 @default.
• W2035982783 hasRelatedWork W128409938 @default.
• W2035982783 hasRelatedWork W1594042095 @default.
• W2035982783 hasRelatedWork W1976065387 @default.
• W2035982783 hasRelatedWork W2016564814 @default.
• W2035982783 hasRelatedWork W2046622327 @default.

• next