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- W2035985490 abstract "L-alanosine (NSC 15353) is a newly developed antitumor antibiotic which acts as an inhibitor of purine intermediary metabolism. Experimental antitumor activity was demonstrated in a variety of murine neoplasms. A Phase I trial was undertaken on a daily x 5 (d x 5) schedule in 22 evaluable patients. Dose limiting toxicity was an oral mucositis characterized by beefy red oral, lingual and pharyngeal erythema. The maximum tolerated dose is 320 mg/m2/d x 5 every three weeks. The recommended dose for Phase II evaluation is 160 mg/m2/d x 5 every three weeks." @default.
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- W2035985490 date "1983-02-01" @default.
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- W2035985490 title "Phase I study of L-alanosine (NSC 15353)" @default.
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- W2035985490 doi "https://doi.org/10.1002/1097-0142(19830201)51:3<378::aid-cncr2820510303>3.0.co;2-i" @default.
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