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• W2035994073 abstract "1. Studies on electrogenesis in cockroach muscle have been repeated under experimental conditions which ensure that the active, electrogenie component of Em is fully functional. 2. Records in haemolymph and in HCO3−saline suggest that the latter is an excellent substitute in the maintenance of excitatory potentials. 3. Both the excitatory post-synaptic potential and electrically excited response were dependent on [Na+]o and small depolarizations were recorded when [Na+]o = [Na+]1. Studies with tritiated inulin suggest that such findings are not due to faulty equilibration. 4. Li+ can act as a partial substitute for Na+ in the saline. 5. Lowered temperature, an elevation of [K+]o or removal of Cl− from the saline all produced a depolarization and a modification of excitatory electrogenesis. At a temperature of 5°C or in the presence of ouabain or metabolic inhibitors the muscle became inexcitable. 6. Excitation is discussed in a system where approximately 18mV of Em are contributed by an electrogenic, active component and 42 mV by an ionic electrode. It is suggested that excitatory electrogenesis is achieved by a limited, non-selective increase in cation permeability, such that tPNa⋍l·5 × PK during excitation. 7. Theoretical considerations in such a system show how excitation could be achieved when [Na+]o = [Na+]i. 8. It is emphasized that the experimental results show clear parallels with those obtained in other input components. 9. The nature of the EPSP and EER are discussed and the problems associated with the production of an IPSP in such a two-component system are considered." @default.
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• W2035994073 date "1974-08-01" @default.
• W2035994073 modified "2023-09-29" @default.
• W2035994073 title "Electrogenesis in cockroach muscle" @default.
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• W2035994073 doi "https://doi.org/10.1016/0300-9629(74)90620-3" @default.
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