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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036002012> ?p ?o ?g. }

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• W2036002012 abstract "We prepared fusion proteins with an alpha subunit of G protein Gi (Gi1alpha) of 26 orphan G protein-coupled receptors (GPCRs) and with Gsalpha of 10 orphan GPCRs, most of which had been identified from the human genome previously [FEBS Lett 520 (2002) 97]. Ligands for these fusion proteins were screened from a library consisting of approximately 1000 authentic compounds by measuring their effect on [35S]GTPgammaS binding to membrane preparations of insect Sf9 cells expressing these fusion proteins. Eleven compounds were found to act as surrogate agonists for a GPCR-Gsalpha and four GPCR-Gialpha fusion proteins, a compound as an inverse agonist for two GPCR-Gsalpha fusion proteins, and a compound as an endogenous agonist for a GPCR-Gialpha fusion protein." @default.
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• W2036002012 date "2003-12-01" @default.
• W2036002012 modified "2023-10-01" @default.
• W2036002012 title "Identification of surrogate ligands for orphan G protein-coupled receptors" @default.
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• W2036002012 doi "https://doi.org/10.1016/j.lfs.2003.09.030" @default.
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