FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036025730> ?p ?o ?g. }

• W2036025730 endingPage "111" @default.
• W2036025730 startingPage "105" @default.
• W2036025730 abstract "This work aims to develop norfloxacin-loaded solid lipid nanoparticle (NFX-SLN) suspensions as a novel formulation. NFX-SLN suspensions were prepared by hot homogenization and ultrasonic technique. The stability of the suspensions was studied after stored at 4 °C and room temperature from 3 to 9 months. The physicochemical characteristics of the NFX-SLN, in vitro release patterns, in vitro antibacterial activity and in vivo therapeutic efficacy in mice after infection with Escherichia coli were conducted and used to evaluate the stability of the suspension. The results showed that the mean diameter (MD), polydispersity index (PDI), zeta potential (ZP) and loading capacity (LC) of nanoparticles were 250 ± 5 nm, 0.256 ± 0.065, −31.1 ± 1.85 mV and 9.63 ± 0.16%, respectively. After 9 months of storage at 4 °C, the NFX-SLN showed no significant changes in MD, PDI and LC except a miner change in ZP. Moreover, the stored suspension displayed same sustained release patterns and in vitro sustained bactericidal activities as that of the fresh preparation. In vivo therapeutic results revealed that the stored suspension had similar enhanced therapeutic efficacy as the fresh preparation compared with native drug. At room temperature the formulation was stable for 3 months, but the LC, ZP and PDI changed and the suspension displayed accelerated release and weakened in vitro antibacterial activity after 6 months. These results demonstrate that NFX-SLN suspensions could be a promising formulation for enhanced pharmacological activity of norfloxacin and were stable at 4 °C and less stable at room temperature." @default.
• W2036025730 created "2016-06-24" @default.
• W2036025730 creator A5003642180 @default.
• W2036025730 creator A5015264393 @default.
• W2036025730 creator A5024178292 @default.
• W2036025730 creator A5032133232 @default.
• W2036025730 creator A5033987340 @default.
• W2036025730 creator A5037595650 @default.
• W2036025730 creator A5040436424 @default.
• W2036025730 creator A5056517476 @default.
• W2036025730 creator A5071030446 @default.
• W2036025730 date "2012-10-01" @default.
• W2036025730 modified "2023-10-17" @default.
• W2036025730 title "Preparation and stability study of norfloxacin-loaded solid lipid nanoparticle suspensions" @default.
• W2036025730 cites W1579046626 @default.
• W2036025730 cites W1964026121 @default.
• W2036025730 cites W1968631214 @default.
• W2036025730 cites W1974789603 @default.
• W2036025730 cites W1991285135 @default.
• W2036025730 cites W1997988583 @default.
• W2036025730 cites W1999122040 @default.
• W2036025730 cites W2005065638 @default.
• W2036025730 cites W2005180863 @default.
• W2036025730 cites W2009760519 @default.
• W2036025730 cites W2021869241 @default.
• W2036025730 cites W2026558149 @default.
• W2036025730 cites W2028565325 @default.
• W2036025730 cites W2033063747 @default.
• W2036025730 cites W2040526113 @default.
• W2036025730 cites W2044681516 @default.
• W2036025730 cites W2053249653 @default.
• W2036025730 cites W2054189154 @default.
• W2036025730 cites W2054727211 @default.
• W2036025730 cites W2055449190 @default.
• W2036025730 cites W2062191794 @default.
• W2036025730 cites W2070182118 @default.
• W2036025730 cites W2080914341 @default.
• W2036025730 cites W2086506126 @default.
• W2036025730 cites W2091024871 @default.
• W2036025730 cites W2091368749 @default.
• W2036025730 cites W2101359892 @default.
• W2036025730 cites W2113717321 @default.
• W2036025730 cites W2117576781 @default.
• W2036025730 cites W2128252087 @default.
• W2036025730 cites W2138267332 @default.
• W2036025730 cites W2150236873 @default.
• W2036025730 cites W2154416862 @default.
• W2036025730 cites W2167168860 @default.
• W2036025730 cites W2168691817 @default.
• W2036025730 cites W2403886093 @default.
• W2036025730 cites W4234521239 @default.
• W2036025730 doi "https://doi.org/10.1016/j.colsurfb.2012.05.006" @default.
• W2036025730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22659379" @default.
• W2036025730 hasPublicationYear "2012" @default.
• W2036025730 type Work @default.
• W2036025730 sameAs 2036025730 @default.
• W2036025730 citedByCount "56" @default.
• W2036025730 countsByYear W20360257302013 @default.
• W2036025730 countsByYear W20360257302014 @default.
• W2036025730 countsByYear W20360257302015 @default.
• W2036025730 countsByYear W20360257302016 @default.
• W2036025730 countsByYear W20360257302017 @default.
• W2036025730 countsByYear W20360257302018 @default.
• W2036025730 countsByYear W20360257302019 @default.
• W2036025730 countsByYear W20360257302020 @default.
• W2036025730 countsByYear W20360257302021 @default.
• W2036025730 countsByYear W20360257302022 @default.
• W2036025730 countsByYear W20360257302023 @default.
• W2036025730 crossrefType "journal-article" @default.
• W2036025730 hasAuthorship W2036025730A5003642180 @default.
• W2036025730 hasAuthorship W2036025730A5015264393 @default.
• W2036025730 hasAuthorship W2036025730A5024178292 @default.
• W2036025730 hasAuthorship W2036025730A5032133232 @default.
• W2036025730 hasAuthorship W2036025730A5033987340 @default.
• W2036025730 hasAuthorship W2036025730A5037595650 @default.
• W2036025730 hasAuthorship W2036025730A5040436424 @default.
• W2036025730 hasAuthorship W2036025730A5056517476 @default.
• W2036025730 hasAuthorship W2036025730A5071030446 @default.
• W2036025730 hasConcept C105341887 @default.
• W2036025730 hasConcept C11432220 @default.
• W2036025730 hasConcept C147789679 @default.
• W2036025730 hasConcept C150903083 @default.
• W2036025730 hasConcept C155672457 @default.
• W2036025730 hasConcept C171250308 @default.
• W2036025730 hasConcept C178790620 @default.
• W2036025730 hasConcept C185592680 @default.
• W2036025730 hasConcept C187530423 @default.
• W2036025730 hasConcept C192562407 @default.
• W2036025730 hasConcept C199529486 @default.
• W2036025730 hasConcept C202444582 @default.
• W2036025730 hasConcept C202751555 @default.
• W2036025730 hasConcept C207001950 @default.
• W2036025730 hasConcept C2778512257 @default.
• W2036025730 hasConcept C2778746504 @default.
• W2036025730 hasConcept C2780104969 @default.
• W2036025730 hasConcept C33923547 @default.
• W2036025730 hasConcept C43617362 @default.
• W2036025730 hasConcept C501593827 @default.

• next