FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036032013> ?p ?o ?g. }

• W2036032013 endingPage "6705" @default.
• W2036032013 startingPage "6693" @default.
• W2036032013 abstract "Our recent studies indicate that endoplasmic reticulum (ER) stress causes INS-1 cell apoptosis by a Ca(2+)-independent phospholipase A(2) (iPLA(2)beta)-mediated mechanism that promotes ceramide generation via sphingomyelin hydrolysis and subsequent activation of the intrinsic pathway. To elucidate the association between iPLA(2)beta and ER stress, we compared beta-cell lines generated from wild type (WT) and Akita mice. The Akita mouse is a spontaneous model of ER stress that develops hyperglycemia/diabetes due to ER stress-induced beta-cell apoptosis. Consistent with a predisposition to developing ER stress, basal phosphorylated PERK and activated caspase-3 are higher in the Akita cells than WT cells. Interestingly, basal iPLA(2)beta, mature SREBP-1 (mSREBP-1), phosphorylated Akt, and neutral sphingomyelinase (NSMase) are higher, relative abundances of sphingomyelins are lower, and mitochondrial membrane potential (DeltaPsi) is compromised in Akita cells, in comparison with WT cells. Exposure to thapsigargin accelerates DeltaPsi loss and apoptosis of Akita cells and is associated with increases in iPLA(2)beta, mSREBP-1, and NSMase in both WT and Akita cells. Transfection of Akita cells with iPLA(2)beta small interfering RNA, however, suppresses NSMase message, DeltaPsi loss, and apoptosis. The iPLA(2)beta gene contains a sterol-regulatory element, and transfection with a dominant negative SREBP-1 reduces basal mSREBP-1 and iPLA(2)beta in the Akita cells and suppresses increases in mSREBP-1 and iPLA(2)beta due to thapsigargin. These findings suggest that ER stress leads to generation of mSREBP-1, which can bind to the sterol-regulatory element in the iPLA(2)beta gene to promote its transcription. Consistent with this, SREBP-1, iPLA(2)beta, and NSMase messages in Akita mouse islets are higher than in WT islets." @default.
• W2036032013 created "2016-06-24" @default.
• W2036032013 creator A5002748082 @default.
• W2036032013 creator A5019318956 @default.
• W2036032013 creator A5047855118 @default.
• W2036032013 creator A5049632995 @default.
• W2036032013 creator A5059422942 @default.
• W2036032013 creator A5060184457 @default.
• W2036032013 creator A5062731143 @default.
• W2036032013 creator A5086320327 @default.
• W2036032013 date "2010-02-01" @default.
• W2036032013 modified "2023-10-03" @default.
• W2036032013 title "Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A2 Expression" @default.
• W2036032013 cites W1505761263 @default.
• W2036032013 cites W1543816617 @default.
• W2036032013 cites W1570888466 @default.
• W2036032013 cites W1765185969 @default.
• W2036032013 cites W1865758164 @default.
• W2036032013 cites W1955419087 @default.
• W2036032013 cites W1966556984 @default.
• W2036032013 cites W1967798906 @default.
• W2036032013 cites W1969690844 @default.
• W2036032013 cites W1969724103 @default.
• W2036032013 cites W1971800301 @default.
• W2036032013 cites W1975780823 @default.
• W2036032013 cites W1977595115 @default.
• W2036032013 cites W1980266047 @default.
• W2036032013 cites W1980456240 @default.
• W2036032013 cites W1983404301 @default.
• W2036032013 cites W1990596987 @default.
• W2036032013 cites W1992748149 @default.
• W2036032013 cites W1999337285 @default.
• W2036032013 cites W1999705714 @default.
• W2036032013 cites W2005542209 @default.
• W2036032013 cites W2013389100 @default.
• W2036032013 cites W2014999693 @default.
• W2036032013 cites W2021581111 @default.
• W2036032013 cites W2026541693 @default.
• W2036032013 cites W2026758511 @default.
• W2036032013 cites W2028526641 @default.
• W2036032013 cites W2031475525 @default.
• W2036032013 cites W2037140370 @default.
• W2036032013 cites W2039999119 @default.
• W2036032013 cites W2045032488 @default.
• W2036032013 cites W2045125428 @default.
• W2036032013 cites W2046563296 @default.
• W2036032013 cites W2050371773 @default.
• W2036032013 cites W2051823539 @default.
• W2036032013 cites W2062378136 @default.
• W2036032013 cites W2063120888 @default.
• W2036032013 cites W2069819213 @default.
• W2036032013 cites W2073028327 @default.
• W2036032013 cites W2074943389 @default.
• W2036032013 cites W2077577428 @default.
• W2036032013 cites W2078856211 @default.
• W2036032013 cites W2090847725 @default.
• W2036032013 cites W2102909249 @default.
• W2036032013 cites W2107601804 @default.
• W2036032013 cites W2111205934 @default.
• W2036032013 cites W2113544353 @default.
• W2036032013 cites W2117559470 @default.
• W2036032013 cites W2118829336 @default.
• W2036032013 cites W2119902047 @default.
• W2036032013 cites W2123105623 @default.
• W2036032013 cites W2123652234 @default.
• W2036032013 cites W2125871871 @default.
• W2036032013 cites W2126793458 @default.
• W2036032013 cites W2127639686 @default.
• W2036032013 cites W2127825630 @default.
• W2036032013 cites W2128340471 @default.
• W2036032013 cites W2131875219 @default.
• W2036032013 cites W2134205408 @default.
• W2036032013 cites W2136209215 @default.
• W2036032013 cites W2141063928 @default.
• W2036032013 cites W2149721868 @default.
• W2036032013 cites W2153178365 @default.
• W2036032013 cites W2154202891 @default.
• W2036032013 cites W2155562978 @default.
• W2036032013 cites W2155945227 @default.
• W2036032013 cites W2165160052 @default.
• W2036032013 cites W4254720972 @default.
• W2036032013 cites W4256495376 @default.
• W2036032013 doi "https://doi.org/10.1074/jbc.m109.084293" @default.
• W2036032013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825464" @default.
• W2036032013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20032468" @default.
• W2036032013 hasPublicationYear "2010" @default.
• W2036032013 type Work @default.
• W2036032013 sameAs 2036032013 @default.
• W2036032013 citedByCount "57" @default.
• W2036032013 countsByYear W20360320132012 @default.
• W2036032013 countsByYear W20360320132013 @default.
• W2036032013 countsByYear W20360320132014 @default.
• W2036032013 countsByYear W20360320132015 @default.
• W2036032013 countsByYear W20360320132016 @default.
• W2036032013 countsByYear W20360320132017 @default.
• W2036032013 countsByYear W20360320132018 @default.
• W2036032013 countsByYear W20360320132019 @default.
• W2036032013 countsByYear W20360320132020 @default.

• next