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- W2036039549 endingPage "161" @default.
- W2036039549 startingPage "153" @default.
- W2036039549 abstract "Endothelins (ET-1, ET-2 and ET-3) are a family of 21 amino acid peptides produced by endothelial cells. They are thought to regulate the local vasomotor tone with endothelium-derived relaxing factors. ETs are the most potent vasoconstrictor substances yet identified and veins and renal vasculature are the most sensitive targets. They reduce cardiac output and have positive inotropic and chronotropic effects. ETs increase the secretion of atrial natriuretic peptide (ANP), aldosterone and catecholamines but reduce renal blood flow and glomerular filtration and they also have mitogenic properties. ETs bind to receptors (ETA and ETB), activate phospholipase C, modulate intraceliular Ca2+ concentration and open Ca2+ channels. Vasoactive agents (adrenaline, angiotensin, vasopressin, thrombin, endotoxins) and hypoxia stimulate the release of ET and also ET gene expression. Raised concentrations of plasma ET have been found to occur in several clinical conditions such as hypertension, myocardial infarction, cardiogenic shock, pregnancy induced hypertension, arteriosclerosis, Raynaud's disease, subarach-noid haemorrhage, uraemia, ulcerative colitis, Crohn's disease and surgical operations suggesting that ETs have a role in several patophysiological processes." @default.
- W2036039549 created "2016-06-24" @default.
- W2036039549 creator A5020102435 @default.
- W2036039549 creator A5069650608 @default.
- W2036039549 date "1992-01-01" @default.
- W2036039549 modified "2023-10-17" @default.
- W2036039549 title "Endothelin Peptides: Biological Activities, Cellular Signalling and Clinical Significance" @default.
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