Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036039953> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2036039953 endingPage "391" @default.
- W2036039953 startingPage "380" @default.
- W2036039953 abstract "Recent studies of rat erythrocyte membranes demonstrated that the transfer of methyl groups to phosphatidylethanolamine significantly altered membrane structure and function. Because membrane alterations were reported in red blood cells from patients with myotonic muscular dystrophy and Duchenne muscular dystrophy, we investigated these reactions as a potential explanation for the membrane defects of these disorders. Human erythrocyte membranes were found to catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to phosphatidylethanolamine to form successively N-monomethyl-phosphatidylethanolamine (PMME), N,N-dimethylphosphatidylethanolamine (PDME), and phosphatidylcholine (PC). The half-maximal rate of [3H]methyl incorporation into PMME and PDME occurred at lower concentrations of SAM (3 and 11 μM, respectively) than that (46 μm) needed for the incorporation into PC. Phospholipid methyltransferase activities in erythrocyte membranes increased with the age of the subject. Five of seven female patients with myotonic muscular dystrophy possessed elevated rates of phospholipid methylation compared with their sex- and age-matched controls. The formation of PC in the red blood cells of one female patient were enhanced over a wide range of SAM concentrations indicating an increased Vmax rather than an altered Km. In contrast, male patients with myotonic dystrophy or with Duchenne muscular dystrophy had similar activities relative to age- and sex-matched controls. Because only female patients with myotonic muscular dystrophy demonstrated an alteration in phospholipid methylation, these reactions do not represent the primary metabolic defect in either dystrophic disorder. However, these results suggest that an increased conversion of PE to PC may influence the expression of the primary defect especially in older female patients." @default.
- W2036039953 created "2016-06-24" @default.
- W2036039953 creator A5015630437 @default.
- W2036039953 creator A5065077745 @default.
- W2036039953 date "1980-11-01" @default.
- W2036039953 modified "2023-09-26" @default.
- W2036039953 title "Methylation of erythrocyte membrane phospholipids in patients with myotonic and Duchenne muscular dystrophy" @default.
- W2036039953 cites W1775749144 @default.
- W2036039953 cites W1842427001 @default.
- W2036039953 cites W1965536329 @default.
- W2036039953 cites W1969379794 @default.
- W2036039953 cites W1979202670 @default.
- W2036039953 cites W1984105204 @default.
- W2036039953 cites W1984774671 @default.
- W2036039953 cites W1987145126 @default.
- W2036039953 cites W1988200876 @default.
- W2036039953 cites W2011044450 @default.
- W2036039953 cites W2025889808 @default.
- W2036039953 cites W2026651960 @default.
- W2036039953 cites W2037773834 @default.
- W2036039953 cites W2071677176 @default.
- W2036039953 cites W2076865848 @default.
- W2036039953 cites W2166241819 @default.
- W2036039953 cites W4251848592 @default.
- W2036039953 cites W77259799 @default.
- W2036039953 doi "https://doi.org/10.1016/0014-4886(80)90035-7" @default.
- W2036039953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7428902" @default.
- W2036039953 hasPublicationYear "1980" @default.
- W2036039953 type Work @default.
- W2036039953 sameAs 2036039953 @default.
- W2036039953 citedByCount "14" @default.
- W2036039953 countsByYear W20360399532013 @default.
- W2036039953 countsByYear W20360399532021 @default.
- W2036039953 crossrefType "journal-article" @default.
- W2036039953 hasAuthorship W2036039953A5015630437 @default.
- W2036039953 hasAuthorship W2036039953A5065077745 @default.
- W2036039953 hasConcept C126322002 @default.
- W2036039953 hasConcept C134018914 @default.
- W2036039953 hasConcept C185592680 @default.
- W2036039953 hasConcept C2776330855 @default.
- W2036039953 hasConcept C2776557347 @default.
- W2036039953 hasConcept C2778063965 @default.
- W2036039953 hasConcept C2778918659 @default.
- W2036039953 hasConcept C2778943923 @default.
- W2036039953 hasConcept C2779030066 @default.
- W2036039953 hasConcept C2781170229 @default.
- W2036039953 hasConcept C33288867 @default.
- W2036039953 hasConcept C41625074 @default.
- W2036039953 hasConcept C552990157 @default.
- W2036039953 hasConcept C55493867 @default.
- W2036039953 hasConcept C71924100 @default.
- W2036039953 hasConcept C86803240 @default.
- W2036039953 hasConceptScore W2036039953C126322002 @default.
- W2036039953 hasConceptScore W2036039953C134018914 @default.
- W2036039953 hasConceptScore W2036039953C185592680 @default.
- W2036039953 hasConceptScore W2036039953C2776330855 @default.
- W2036039953 hasConceptScore W2036039953C2776557347 @default.
- W2036039953 hasConceptScore W2036039953C2778063965 @default.
- W2036039953 hasConceptScore W2036039953C2778918659 @default.
- W2036039953 hasConceptScore W2036039953C2778943923 @default.
- W2036039953 hasConceptScore W2036039953C2779030066 @default.
- W2036039953 hasConceptScore W2036039953C2781170229 @default.
- W2036039953 hasConceptScore W2036039953C33288867 @default.
- W2036039953 hasConceptScore W2036039953C41625074 @default.
- W2036039953 hasConceptScore W2036039953C552990157 @default.
- W2036039953 hasConceptScore W2036039953C55493867 @default.
- W2036039953 hasConceptScore W2036039953C71924100 @default.
- W2036039953 hasConceptScore W2036039953C86803240 @default.
- W2036039953 hasIssue "2" @default.
- W2036039953 hasLocation W20360399531 @default.
- W2036039953 hasLocation W20360399532 @default.
- W2036039953 hasOpenAccess W2036039953 @default.
- W2036039953 hasPrimaryLocation W20360399531 @default.
- W2036039953 hasRelatedWork W1965127375 @default.
- W2036039953 hasRelatedWork W2005445152 @default.
- W2036039953 hasRelatedWork W2009240753 @default.
- W2036039953 hasRelatedWork W2036039953 @default.
- W2036039953 hasRelatedWork W2047947260 @default.
- W2036039953 hasRelatedWork W2092576333 @default.
- W2036039953 hasRelatedWork W3031319756 @default.
- W2036039953 hasRelatedWork W77534462 @default.
- W2036039953 hasRelatedWork W950194781 @default.
- W2036039953 hasRelatedWork W2156078707 @default.
- W2036039953 hasVolume "70" @default.
- W2036039953 isParatext "false" @default.
- W2036039953 isRetracted "false" @default.
- W2036039953 magId "2036039953" @default.
- W2036039953 workType "article" @default.