FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036040400> ?p ?o ?g. }

• W2036040400 endingPage "402" @default.
• W2036040400 startingPage "391" @default.
• W2036040400 abstract "Increased plasma total homocysteine (tHcy), a risk factor for cardiovascular disease, is related to genetic, environmental, and nutritional factors, in particular folate status. Future large epidemiologic studies of the genetic basis of hyperhomocysteinemia will require high-throughput assays for polymorphisms of genes related to folate and Hcy metabolism.We developed a high-level multiplex genotyping method based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the detection of 12 polymorphisms in 8 genes involved in folate or Hcy metabolism. The assay includes methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G, cystathionine beta-synthase (CBS) 844ins68 and 699C>T, transcobalamin II (TCII) 776C>G and 67A>G, reduced folate carrier-1 (RFC1) 80G>A, paraoxonase-1 (PON1) 575A>G and 163T>A, and betaine homocysteine methyltransferase (BHMT) 742G>A.The failure rate of the assay was < or = 1.7% and was attributable to unsuccessful DNA purification, nanoliter dispensing, and spectrum calibration. Most errors were related to identification of heterozygotes as homozygotes. The mean error rate was 0.26%, and error rates differed for the various single-nucleotide polymorphisms. Identification of CBS 844ins68 was carried out by a semiquantitative approach. The throughput of the MALDI-TOF MS assay was 1152 genotypes within 20 min.This high-level multiplex method is able to genotype 12 polymorphisms involved in folate or Hcy metabolism. The method is rapid and reproducible and could facilitate large-scale studies of the genetic basis of hyperhomocysteinemia and associated pathologies." @default.
• W2036040400 created "2016-06-24" @default.
• W2036040400 creator A5026276538 @default.
• W2036040400 creator A5039611683 @default.
• W2036040400 creator A5086031444 @default.
• W2036040400 date "2004-02-01" @default.
• W2036040400 modified "2023-10-10" @default.
• W2036040400 title "High-Level Multiplex Genotyping of Polymorphisms Involved in Folate or Homocysteine Metabolism by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry" @default.
• W2036040400 cites W1572305422 @default.
• W2036040400 cites W1589411629 @default.
• W2036040400 cites W1622309784 @default.
• W2036040400 cites W1873399771 @default.
• W2036040400 cites W1896684000 @default.
• W2036040400 cites W1966251853 @default.
• W2036040400 cites W1975066367 @default.
• W2036040400 cites W1975191556 @default.
• W2036040400 cites W1978745643 @default.
• W2036040400 cites W1983419413 @default.
• W2036040400 cites W1987666378 @default.
• W2036040400 cites W1995781460 @default.
• W2036040400 cites W1996415245 @default.
• W2036040400 cites W1998867353 @default.
• W2036040400 cites W2005193926 @default.
• W2036040400 cites W2021624451 @default.
• W2036040400 cites W2023172570 @default.
• W2036040400 cites W2024897738 @default.
• W2036040400 cites W2031262735 @default.
• W2036040400 cites W2031411555 @default.
• W2036040400 cites W2034588913 @default.
• W2036040400 cites W2038717263 @default.
• W2036040400 cites W2038825083 @default.
• W2036040400 cites W2040033652 @default.
• W2036040400 cites W2041051368 @default.
• W2036040400 cites W2044170424 @default.
• W2036040400 cites W2049439467 @default.
• W2036040400 cites W2049485050 @default.
• W2036040400 cites W2059190573 @default.
• W2036040400 cites W2059297225 @default.
• W2036040400 cites W2059469231 @default.
• W2036040400 cites W2062567078 @default.
• W2036040400 cites W2063790852 @default.
• W2036040400 cites W2064241142 @default.
• W2036040400 cites W2070009272 @default.
• W2036040400 cites W2071269027 @default.
• W2036040400 cites W2077309813 @default.
• W2036040400 cites W2077550989 @default.
• W2036040400 cites W2078818650 @default.
• W2036040400 cites W2085341524 @default.
• W2036040400 cites W2088328517 @default.
• W2036040400 cites W2089053696 @default.
• W2036040400 cites W2090057750 @default.
• W2036040400 cites W2093166014 @default.
• W2036040400 cites W2095167826 @default.
• W2036040400 cites W2097731163 @default.
• W2036040400 cites W2107208250 @default.
• W2036040400 cites W2108484297 @default.
• W2036040400 cites W2112989503 @default.
• W2036040400 cites W2115698806 @default.
• W2036040400 cites W2126733000 @default.
• W2036040400 cites W2132819133 @default.
• W2036040400 cites W2133194323 @default.
• W2036040400 cites W2138418212 @default.
• W2036040400 cites W2145839720 @default.
• W2036040400 cites W2148708125 @default.
• W2036040400 cites W2153856509 @default.
• W2036040400 cites W2164911583 @default.
• W2036040400 cites W2165715420 @default.
• W2036040400 cites W2170304711 @default.
• W2036040400 cites W2314454781 @default.
• W2036040400 cites W4234161075 @default.
• W2036040400 cites W4319718394 @default.
• W2036040400 doi "https://doi.org/10.1373/clinchem.2003.026799" @default.
• W2036040400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14752013" @default.
• W2036040400 hasPublicationYear "2004" @default.
• W2036040400 type Work @default.
• W2036040400 sameAs 2036040400 @default.
• W2036040400 citedByCount "50" @default.
• W2036040400 countsByYear W20360404002012 @default.
• W2036040400 countsByYear W20360404002013 @default.
• W2036040400 countsByYear W20360404002014 @default.
• W2036040400 countsByYear W20360404002016 @default.
• W2036040400 countsByYear W20360404002017 @default.
• W2036040400 countsByYear W20360404002018 @default.
• W2036040400 countsByYear W20360404002020 @default.
• W2036040400 countsByYear W20360404002022 @default.
• W2036040400 countsByYear W20360404002023 @default.
• W2036040400 crossrefType "journal-article" @default.
• W2036040400 hasAuthorship W2036040400A5026276538 @default.
• W2036040400 hasAuthorship W2036040400A5039611683 @default.
• W2036040400 hasAuthorship W2036040400A5086031444 @default.
• W2036040400 hasBestOaLocation W20360404001 @default.
• W2036040400 hasConcept C104317684 @default.
• W2036040400 hasConcept C135763542 @default.
• W2036040400 hasConcept C153911025 @default.
• W2036040400 hasConcept C16525657 @default.
• W2036040400 hasConcept C181199279 @default.
• W2036040400 hasConcept C185592680 @default.
• W2036040400 hasConcept C2776523773 @default.

• next