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- W2036058369 abstract "Objective To conduct an anonymous HIV seroprevalence survey to establish a baseline estimate of HIV seroprevalence in a general population; to evaluate serum pooling, and alternative testing strategies as cost-saving measures. Design Prospective anonymous HIV seroprevalence study using outpatient laboratory specimens. Setting Two large non-hospital-associated outpatient chemistry testing laboratories in the major population centers in British Columbia, Canada. Patients , and sera: Leftover sera received for chemistry screen testing in outpatient laboratories were provided to the study after chemistry testing was completed. Those from patients aged <15, and ≥55 years were excluded. Methods Patient identifiers were erased from samples. Sera were pooled 10:1, and tested by viral lysate enzyme-linked immunosorbent assay (ELISA). Sera from HIV-positive pools were tested individually. All individual HIV-positive specimens were retested for verification of positivity using a recombinant protein ELISA. Main outcome measures HIV seroprevalence rates were stratified by sex, age group, and geographic area;, and costs of pooling, and alternative algorithm strategy were compared with those of conventional methods. Results A total of 80238 sera were collected from 66 658 individuals (53% women, 47% men). Of these, 276 men (88.3 per 10 000), and 24 women (6.8 per 10 000) were HIV-seropositive. The highest rates were in those aged 30–34 years, for both men, and women. Using pooling, and non-Western blot verification saved US$ 2.07 per specimen, or 80% of the cost for conventional testing. Conclusions The anonymous outpatient laboratory setting is practicable to obtain a reasonable estimate of HIV seroprevalence rates in a general population. Such studies can be made cost-effective by pooling sera, and using alternative confirmatory strategies." @default.
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- W2036058369 title "Use of pooling, and outpatient laboratory specimens in an anonymous seroprevalence survey of HIV infection in British Columbia, Canada" @default.
- W2036058369 doi "https://doi.org/10.1097/00002030-199508000-00017" @default.
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