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- W2036061808 abstract "Background and purpose To analyse biochemical relapse-free-survival results for prostate cancer patients receiving combined external beam and high-dose-rate brachytherapy, in comparison with expected results using projections based on dose/fractionation/response parameter values deduced from a previous external-beam-alone 5969-patient multicentre dataset. Material and methods Results on a total of 3145 prostate cancer patients receiving brachytherapy (BT) as part or all of their treatment were collected from 10 institutions, and subjected to linear-quadratic (LQ) modelling of dose response and fractionation parameters. Results Treatments with BT components of less than 25 Gy, 3–4 BT fractions, doses per BT fraction up to 6 Gy, and treatment times of 3–7 weeks, all gave outcomes expected from LQ projections of the external-beam-alone data (α/β = 1.42 Gy). However, BT doses higher than 30 Gy, 1–2 fractions, 9 fractions (BT alone), doses per fraction of 9–15 Gy, and treatment in only 1 week (one example), gave local control levels lower than the expected levels by up to ∼35%. Conclusions There are various potential causes of the lower-than-projected control levels for some schedules of brachytherapy: it seems plausible that cold spots in the brachytherapy dose distribution may be contributory, and the applicability of the LQ model at high doses per fraction remains somewhat uncertain. The results of further trials may help elucidate the true benefit of hypofractionated high-dose-rate brachytherapy." @default.
- W2036061808 created "2016-06-24" @default.
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- W2036061808 date "2014-04-01" @default.
- W2036061808 modified "2023-10-18" @default.
- W2036061808 title "A modelled comparison of prostate cancer control rates after high-dose-rate brachytherapy (3145 multicentre patients) combined with, or in contrast to, external-beam radiotherapy" @default.
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- W2036061808 doi "https://doi.org/10.1016/j.radonc.2014.01.008" @default.
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