Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036062398> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2036062398 endingPage "42" @default.
- W2036062398 startingPage "33" @default.
- W2036062398 abstract "Natural killer (NK) cells control Mycobacterium tuberculosis infection mainly through secreted cytokines. Cytokine dysregulation among HIV may cause rapid disease progression. Our objective was to examine whether impaired production of innate cytokines are responsible for cytokine dysregulation during HIV infection. The study included 30 subjects each of normal healthy subjects (NHS), pulmonary tuberculosis patients (TB), HIV-infected individuals (HIV), and HIV–TB co-infected patients (HIV–TB). Intracellular cytokine staining method was used to enumerate the cytokine-positive NK cells. Unlike NHS (100%), only 27% of HIV–TB and 57% of HIV infected patients have detectable plasma interleukin (IL)-15 levels that signify impaired rather than decreased IL-15 production. Basal type 1 cytokine (IL-2, interferon-γ [IFN-γ], and tumor necrosis factor-α [TNF-α])-secreting NK cells (NK1 cytokines) were decreased significantly (P < 0.05) in TB, HIV, and HIV–TB, when compared with NHS. Stimulation with M. tuberculosis H37Rv enhanced the NK1 cytokines in NHS (P < 0.05), but not in other groups. With IL-15+IL-12 stimulation, we found increased NK1 cytokines (IL-2 and IFN-γ) in HIV (P < 0.05), but not in HIV–TB, when compared to unstimulated condition. Supplementing IL-15+IL-12 has potential in improving the frequency of NK1 cytokines for HIV, but not HIV–TB, suggesting that TB influences cytokine response during HIV infection." @default.
- W2036062398 created "2016-06-24" @default.
- W2036062398 creator A5048998302 @default.
- W2036062398 creator A5055705755 @default.
- W2036062398 creator A5069996307 @default.
- W2036062398 date "2010-01-01" @default.
- W2036062398 modified "2023-10-16" @default.
- W2036062398 title "Natural Killer Cell–Mediated Cytokine Response Among HIV-Positive South Indians With Pulmonary Tuberculosis" @default.
- W2036062398 cites W1499740654 @default.
- W2036062398 cites W1614160000 @default.
- W2036062398 cites W1971477398 @default.
- W2036062398 cites W1992185247 @default.
- W2036062398 cites W1995273554 @default.
- W2036062398 cites W2002483968 @default.
- W2036062398 cites W2003947050 @default.
- W2036062398 cites W2006073656 @default.
- W2036062398 cites W2006494609 @default.
- W2036062398 cites W2028345258 @default.
- W2036062398 cites W2028774908 @default.
- W2036062398 cites W2038699225 @default.
- W2036062398 cites W2060098138 @default.
- W2036062398 cites W2067528418 @default.
- W2036062398 cites W2070650056 @default.
- W2036062398 cites W2084023405 @default.
- W2036062398 cites W2099019634 @default.
- W2036062398 cites W2107357004 @default.
- W2036062398 cites W2109624542 @default.
- W2036062398 cites W2144445894 @default.
- W2036062398 cites W2149051564 @default.
- W2036062398 cites W2162620875 @default.
- W2036062398 cites W2167951497 @default.
- W2036062398 cites W2314331148 @default.
- W2036062398 cites W2332179767 @default.
- W2036062398 doi "https://doi.org/10.1089/jir.2009.0018" @default.
- W2036062398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20028198" @default.
- W2036062398 hasPublicationYear "2010" @default.
- W2036062398 type Work @default.
- W2036062398 sameAs 2036062398 @default.
- W2036062398 citedByCount "9" @default.
- W2036062398 countsByYear W20360623982012 @default.
- W2036062398 countsByYear W20360623982014 @default.
- W2036062398 countsByYear W20360623982016 @default.
- W2036062398 countsByYear W20360623982019 @default.
- W2036062398 countsByYear W20360623982023 @default.
- W2036062398 crossrefType "journal-article" @default.
- W2036062398 hasAuthorship W2036062398A5048998302 @default.
- W2036062398 hasAuthorship W2036062398A5055705755 @default.
- W2036062398 hasAuthorship W2036062398A5069996307 @default.
- W2036062398 hasConcept C142724271 @default.
- W2036062398 hasConcept C164027704 @default.
- W2036062398 hasConcept C17991360 @default.
- W2036062398 hasConcept C203014093 @default.
- W2036062398 hasConcept C2776178377 @default.
- W2036062398 hasConcept C2776914184 @default.
- W2036062398 hasConcept C2777975735 @default.
- W2036062398 hasConcept C2778690821 @default.
- W2036062398 hasConcept C2780841837 @default.
- W2036062398 hasConcept C2781069245 @default.
- W2036062398 hasConcept C71924100 @default.
- W2036062398 hasConceptScore W2036062398C142724271 @default.
- W2036062398 hasConceptScore W2036062398C164027704 @default.
- W2036062398 hasConceptScore W2036062398C17991360 @default.
- W2036062398 hasConceptScore W2036062398C203014093 @default.
- W2036062398 hasConceptScore W2036062398C2776178377 @default.
- W2036062398 hasConceptScore W2036062398C2776914184 @default.
- W2036062398 hasConceptScore W2036062398C2777975735 @default.
- W2036062398 hasConceptScore W2036062398C2778690821 @default.
- W2036062398 hasConceptScore W2036062398C2780841837 @default.
- W2036062398 hasConceptScore W2036062398C2781069245 @default.
- W2036062398 hasConceptScore W2036062398C71924100 @default.
- W2036062398 hasIssue "1" @default.
- W2036062398 hasLocation W20360623981 @default.
- W2036062398 hasLocation W20360623982 @default.
- W2036062398 hasOpenAccess W2036062398 @default.
- W2036062398 hasPrimaryLocation W20360623981 @default.
- W2036062398 hasRelatedWork W1965685424 @default.
- W2036062398 hasRelatedWork W1991464170 @default.
- W2036062398 hasRelatedWork W2070650056 @default.
- W2036062398 hasRelatedWork W2103863744 @default.
- W2036062398 hasRelatedWork W2109624542 @default.
- W2036062398 hasRelatedWork W2145513887 @default.
- W2036062398 hasRelatedWork W2349894740 @default.
- W2036062398 hasRelatedWork W2373481325 @default.
- W2036062398 hasRelatedWork W2407272674 @default.
- W2036062398 hasRelatedWork W4322753727 @default.
- W2036062398 hasVolume "30" @default.
- W2036062398 isParatext "false" @default.
- W2036062398 isRetracted "false" @default.
- W2036062398 magId "2036062398" @default.
- W2036062398 workType "article" @default.