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- W2036066038 abstract "Both oxidative/nitrosative stress and alterations in DNA methylation are observed during carcinogenesis of different tumor types, but no clear correlation between these events has been demonstrated until now. Melanoma cell lines were previously established after submitting the nontumorigenicmelanocyte lineage, melan-a, to cycles of anchorage blockade. In this work, increased intracellular oxidative species and nitric oxide levels, as well as alterations in the DNA methylation, were observed after melan-a detachment, which were also associated with a decrease in intracellular homocysteine (Hcy), an element in the methionine (universal methyl donor) cycle. This alteration was accompanied by increase in glutathione (GSH) levels and methylated DNA content. Furthermore, a significant increase in dnmt1 and 3b expression was identified along melan-a anchorage blockade. L(G)-Nitro-L-arginine methyl esther (L-NAME), known as a nitric oxide synthase (NOS) inhibitor, and N-acetyl-L-cysteine (NAC) prevented the increase in global DNA methylation, as well as the increase in dnmt1 and 3b expression, observed during melan-a detachment. Interestingly, both L-NAME and NAC did not inhibit nitric oxide (NO) production in these cells, but abrogated superoxide anion production during anchorage blockade. In conclusion, oxidative stress observed during melanocyte anchorage blockade seems to modulate DNA methylation levels and may directly contribute to the acquisition of an anoikis-resistant phenotype through an epigenetic mechanism." @default.
- W2036066038 created "2016-06-24" @default.
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- W2036066038 date "2007-12-01" @default.
- W2036066038 modified "2023-10-03" @default.
- W2036066038 title "Oxidative Stress Modulates DNA Methylation during Melanocyte Anchorage Blockade Associated with Malignant Transformation" @default.
- W2036066038 cites W1504303645 @default.
- W2036066038 cites W1775749144 @default.
- W2036066038 cites W1980674137 @default.
- W2036066038 cites W1981615091 @default.
- W2036066038 cites W1982047009 @default.
- W2036066038 cites W1982596539 @default.
- W2036066038 cites W1983310681 @default.
- W2036066038 cites W1985422263 @default.
- W2036066038 cites W1990349961 @default.
- W2036066038 cites W1990562295 @default.
- W2036066038 cites W1992160817 @default.
- W2036066038 cites W2000808749 @default.
- W2036066038 cites W2003143382 @default.
- W2036066038 cites W2004398529 @default.
- W2036066038 cites W2007064404 @default.
- W2036066038 cites W2010478333 @default.
- W2036066038 cites W2013450792 @default.
- W2036066038 cites W2018647118 @default.
- W2036066038 cites W2020080089 @default.
- W2036066038 cites W2020600203 @default.
- W2036066038 cites W2020902432 @default.
- W2036066038 cites W2026215531 @default.
- W2036066038 cites W2032120730 @default.
- W2036066038 cites W2033910705 @default.
- W2036066038 cites W2035552286 @default.
- W2036066038 cites W2035744678 @default.
- W2036066038 cites W2036986058 @default.
- W2036066038 cites W2038032266 @default.
- W2036066038 cites W2040754208 @default.
- W2036066038 cites W2042369211 @default.
- W2036066038 cites W2044474149 @default.
- W2036066038 cites W2049169526 @default.
- W2036066038 cites W2049657352 @default.
- W2036066038 cites W2060064603 @default.
- W2036066038 cites W2063978763 @default.
- W2036066038 cites W2065542071 @default.
- W2036066038 cites W2066520082 @default.
- W2036066038 cites W2067819328 @default.
- W2036066038 cites W2072569792 @default.
- W2036066038 cites W2072732992 @default.
- W2036066038 cites W2073159120 @default.
- W2036066038 cites W2075232834 @default.
- W2036066038 cites W2080444484 @default.
- W2036066038 cites W2083445704 @default.
- W2036066038 cites W2091130756 @default.
- W2036066038 cites W2094864890 @default.
- W2036066038 cites W2095236624 @default.
- W2036066038 cites W2096209217 @default.
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- W2036066038 cites W2107818859 @default.
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- W2036066038 cites W2122886873 @default.
- W2036066038 cites W2137983089 @default.
- W2036066038 cites W2140258350 @default.
- W2036066038 cites W2140418591 @default.
- W2036066038 cites W2149689548 @default.
- W2036066038 cites W2149997127 @default.
- W2036066038 cites W2152099942 @default.
- W2036066038 cites W2160851275 @default.
- W2036066038 cites W2169859294 @default.
- W2036066038 cites W2171118724 @default.
- W2036066038 cites W2323139294 @default.
- W2036066038 cites W4232777855 @default.
- W2036066038 cites W4234012592 @default.
- W2036066038 cites W4235517036 @default.
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- W2036066038 doi "https://doi.org/10.1593/neo.07712" @default.
- W2036066038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2134907" @default.
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