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- W2036080133 abstract "In Brief Objective: The objective of this study was to investigate the levels of τ protein in neurosyphilis. Study Design: Total τ protein in the cerebrospinal fluid of 12 patients with neurosyphilis, 17 with syphilis without nervous system involvement, 14 controls, and 14 patients with Alzheimer disease of comparable age were analyzed. Double-sandwich enzyme-linked immunosorbent assay was used for measurements. Results: Increased levels of cerebrospinal fluid total τ were observed in neurosyphilis (median [25th–75th percentile]: 349 pg/mL [312–429]) and in Alzheimer disease (543 [441–1017]) as compared with the controls (189 [106–220]) and syphilis without nervous system involvement (190 [160–223]). Using a cutoff level of 300 pg/mL, increased τ discriminated cases of neurosyphilis from syphilis without nervous system involvement with a sensitivity and specificity of 83% and 94%, respectively. Conclusions: These results indicate that increased total τ may be useful in the discrimination of neurosyphilis from syphilis without nervous system involvement. A study of patients with neurosyphilis found that there is an increased level of cerebrospinal fluid total τ in neurosyphilis as compared with the controls and syphilis without nervous system involvement." @default.
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- W2036080133 date "2007-04-01" @default.
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- W2036080133 title "Cerebrospinal Fluid Tau Protein Is Increased in Neurosyphilis: A Discrimination From Syphilis Without Nervous System Involvement?" @default.
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- W2036080133 doi "https://doi.org/10.1097/01.olq.0000233738.23278.4e" @default.
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