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- W2036112951 startingPage "253" @default.
- W2036112951 abstract "The precerebellar system provides an interesting model to study tangential migrations. All precerebellar neurons (PCN) are generated in the most alar part of the hindbrain in a region called rhombic lip. PCN first emit a leading process and then translocate their nuclei inside it, a mechanism called nucleokinesis. In the past few years, molecular cues that could affect those processes have been investigated, with a special care on: (i) the identification of extrinsic factors directing cell migration and axon elongation as well as neuronal survival during development; (ii) intracellular reorganizations of the cytoskeleton during nucleokinesis in response to chemotropic factors. The signaling cascades, including regulators of actin and microtubule cytoskeleton, in response to diffusible guidance factors have raised an increasing attention. We will here review the role of guidance cues involved in PCN migration in particular netrin-1, Slit and Nr-CAM. We will also consider Rho-GTPases that have been proposed to mediate axon outgrowth and neuronal migration, especially in response to netrin-1, and which may act as a relay between extracellular signals and intracellular remodeling. Recent findings from in vitro pharmacological inhibition of various Rho-GTPases and over-expression of effectors bring molecular cues that, in accordance with anatomical data, fit the idea that nucleokinesis and axon outgrowth are not strictly coupled events during PCN migration." @default.
- W2036112951 created "2016-06-24" @default.
- W2036112951 creator A5007004380 @default.
- W2036112951 creator A5024027203 @default.
- W2036112951 creator A5061903214 @default.
- W2036112951 creator A5065251431 @default.
- W2036112951 creator A5073420011 @default.
- W2036112951 date "2005-09-01" @default.
- W2036112951 modified "2023-10-18" @default.
- W2036112951 title "Development of precerebellar nuclei: instructive factors and intracellular mediators in neuronal migration, survival and axon pathfinding" @default.
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