Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036113447> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2036113447 endingPage "S251" @default.
- W2036113447 startingPage "S251" @default.
- W2036113447 abstract "Conditionally replicative adenoviruses (CRAD, also called oncolytic adenoviruses) are a new platform for the treatment of cancer. Despite the promising results in pre-clinical models, their efficacy in humans is hampered by several factors, including poor biodistribution in solid tumors. Here we describe the construction and characterization of Ad-DHLuc, a new CRAD designed for in vivo evaluation of viral replication and spread under hypoxic conditions. The replication of Ad-DHLuc is directed to solid tumors by different mechanisms: (i) transcriptional control of E1A gene by a hypoxia-responsive promtorer, (ii) transcriptional control of the E4 region by an E2F-responsive promotoer, and (iii) deletion of the CR2 domain of E1A. The virus carries the luciferase gene inserted into the E3 region (substitution of the gp19k/6.7k genes), in order to link transgene expression and viral replication. We provide evidence that the virus is activated by hypoxia in cancer cells. Using bioluminiscence detection and virus quantification, we show that Ad-DHLuc can replicate in human hepatocellular carcinoma xenografts growing in nude mice. This CRAD will allow the evaluation of new strategies aimed to improve the distribution of the virus in solid tumors." @default.
- W2036113447 created "2016-06-24" @default.
- W2036113447 creator A5002412589 @default.
- W2036113447 creator A5003320027 @default.
- W2036113447 creator A5008765932 @default.
- W2036113447 creator A5019534165 @default.
- W2036113447 creator A5045532311 @default.
- W2036113447 date "2006-01-01" @default.
- W2036113447 modified "2023-09-27" @default.
- W2036113447 title "652. In Vivo Evaluation of an Oncolytic Adenovirus Regulated by Hypoxia" @default.
- W2036113447 doi "https://doi.org/10.1016/j.ymthe.2006.08.728" @default.
- W2036113447 hasPublicationYear "2006" @default.
- W2036113447 type Work @default.
- W2036113447 sameAs 2036113447 @default.
- W2036113447 citedByCount "0" @default.
- W2036113447 crossrefType "journal-article" @default.
- W2036113447 hasAuthorship W2036113447A5002412589 @default.
- W2036113447 hasAuthorship W2036113447A5003320027 @default.
- W2036113447 hasAuthorship W2036113447A5008765932 @default.
- W2036113447 hasAuthorship W2036113447A5019534165 @default.
- W2036113447 hasAuthorship W2036113447A5045532311 @default.
- W2036113447 hasBestOaLocation W20361134471 @default.
- W2036113447 hasConcept C102230213 @default.
- W2036113447 hasConcept C104317684 @default.
- W2036113447 hasConcept C111599444 @default.
- W2036113447 hasConcept C140704245 @default.
- W2036113447 hasConcept C150194340 @default.
- W2036113447 hasConcept C159047783 @default.
- W2036113447 hasConcept C207001950 @default.
- W2036113447 hasConcept C2522874641 @default.
- W2036113447 hasConcept C2777283488 @default.
- W2036113447 hasConcept C49744831 @default.
- W2036113447 hasConcept C502942594 @default.
- W2036113447 hasConcept C54355233 @default.
- W2036113447 hasConcept C82210918 @default.
- W2036113447 hasConcept C83258922 @default.
- W2036113447 hasConcept C86803240 @default.
- W2036113447 hasConceptScore W2036113447C102230213 @default.
- W2036113447 hasConceptScore W2036113447C104317684 @default.
- W2036113447 hasConceptScore W2036113447C111599444 @default.
- W2036113447 hasConceptScore W2036113447C140704245 @default.
- W2036113447 hasConceptScore W2036113447C150194340 @default.
- W2036113447 hasConceptScore W2036113447C159047783 @default.
- W2036113447 hasConceptScore W2036113447C207001950 @default.
- W2036113447 hasConceptScore W2036113447C2522874641 @default.
- W2036113447 hasConceptScore W2036113447C2777283488 @default.
- W2036113447 hasConceptScore W2036113447C49744831 @default.
- W2036113447 hasConceptScore W2036113447C502942594 @default.
- W2036113447 hasConceptScore W2036113447C54355233 @default.
- W2036113447 hasConceptScore W2036113447C82210918 @default.
- W2036113447 hasConceptScore W2036113447C83258922 @default.
- W2036113447 hasConceptScore W2036113447C86803240 @default.
- W2036113447 hasLocation W20361134471 @default.
- W2036113447 hasOpenAccess W2036113447 @default.
- W2036113447 hasPrimaryLocation W20361134471 @default.
- W2036113447 hasRelatedWork W1545850408 @default.
- W2036113447 hasRelatedWork W1861506798 @default.
- W2036113447 hasRelatedWork W2047558272 @default.
- W2036113447 hasRelatedWork W2062997542 @default.
- W2036113447 hasRelatedWork W2079316258 @default.
- W2036113447 hasRelatedWork W2101584783 @default.
- W2036113447 hasRelatedWork W2171585481 @default.
- W2036113447 hasRelatedWork W2956138224 @default.
- W2036113447 hasRelatedWork W3029938204 @default.
- W2036113447 hasRelatedWork W181957012 @default.
- W2036113447 hasVolume "13" @default.
- W2036113447 isParatext "false" @default.
- W2036113447 isRetracted "false" @default.
- W2036113447 magId "2036113447" @default.
- W2036113447 workType "article" @default.