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- W2036116083 abstract "<h3>Background</h3> Lipids of TPN can cause liver toxicity in premature infants, so it is important to evaluate the introduction of new emulsions <h3>Purpose</h3> To describe the safety of two lipid emulsions used in the compounding of total parenteral nutrition (TPN) for premature infants. <h3>Materials and methods</h3> A retrospective study of two time periods, 2009 and 2010, of preterm infants population whit TPN. The analysis excluded those cases of death, sepsis and those who had a liver disease. 20 children received parenteral nutrition with lipid emulsion derived from soybean oil (Intralipid ®), from August to December 2009. In the second group were evaluated 19 children, whose lipid emulsion was derived from olive oil (ClinOleic ®) in the period from August to December 2010. The authors evaluated the following criteria: levels of bilirubin and liver enzymes (ALT/AST) and maximum insulin requirements (IU/kg/h). <h3>Results</h3> 39 infants within 72 h of life completed the study. The group that received parenteral nutrition with soybean oil derived (n=20) showed a mean gestational age of 31.4 weeks (27-34) and an average weight of 1.64 kg (0.76-2.8), the second group with lipids olive oil derived (n=19) 30.4 weeks (28-32) of age and weighing 1.82 kg (0.6-.2.28). Bilirubin levels were similar in both groups: soybean 8.4 mg / dl (2.4-20.02) and olive 9.1 mg / dl (2,52-16.9). There were no significant differences in levels of liver enzymes AST of 43.6 U/L (17-235.3) and ALT of 5.21 U/L (4.1-9.2) and oil olive group AST 43.1 U/L (19.2-170.3) and 13.7 U/L (5.2-37.3) ALT. In the study population also did not show higher insulin requirements in any of the two groups referred to maximum needs, 0.034 UI/kg/h (0.02-0.03) versus 0.036 IU/kg/day (0.02-0.035). <h3>Conclusions</h3> Both lipid emulsions were well tolerated, showing no difference in hepatic damage. The results suggest that both lipid preparations have similar safety profile in preterm parenteral nutrition." @default.
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- W2036116083 date "2012-03-12" @default.
- W2036116083 modified "2023-09-27" @default.
- W2036116083 title "Lipids in total parenteral nutrition for premature infants." @default.
- W2036116083 doi "https://doi.org/10.1136/ejhpharm-2012-000074.440" @default.
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