FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036128545> ?p ?o ?g. }

• W2036128545 endingPage "165" @default.
• W2036128545 startingPage "156" @default.
• W2036128545 abstract "Metallothioneins (MTs) are typically low molecular weight (6–7 kDa), metal-binding proteins with characteristic repeating cysteine motifs (Cys–X–Cys or Cys–Xn–Cys) and a prolate ellipsoid shape containing single α- and β-domains. While functionally diverse, they play important roles in metals homeostasis, detoxification and the stress response. The present study, combined with previous observations (e.g., Jenny et al., Eur. J. Biochem. 2005; 271:1702–1712) defines an unprecedented diversity of MT primary structure and domain organization in the American oyster, Crassostrea virginica. Two novel molluscan MT families are described. One of these (CvMT-III) is characterized by the presence of two β-domains and the absence of α-domains. This family exhibits constitutive expression during larval development and is the dominant CvMT isoform expressed in larvae. CvMT-III displays low basal levels of expression in adult tissues and only moderate responsiveness to metal challenges in both larvae and adults. A second novel MT isoform (CvMT-IV) was isolated from hemocytes by subtractive hybridization techniques following a 4-hour immune challenge with heat-killed bacteria (Vibrio, Bacillus, Micrococcus spp. mixture). Based on conservation of the cysteine motifs, this isoform appears to be a sub-family related to the molluscan αβ-domain MTs. A series of amino acid substitutions has resulted in four additional cysteines which give rise to a Cys–Cys motif and three Cys–Cys–Cys motifs. Northern blot analyses demonstrate that CvMT-IV is down-regulated upon sterile wounding and immune challenge, displays moderate expression in larvae and adults and differential gene induction in response to metals exposure." @default.
• W2036128545 created "2016-06-24" @default.
• W2036128545 creator A5007066609 @default.
• W2036128545 creator A5054791894 @default.
• W2036128545 creator A5061622282 @default.
• W2036128545 creator A5065360504 @default.
• W2036128545 creator A5077490350 @default.
• W2036128545 date "2006-09-01" @default.
• W2036128545 modified "2023-10-16" @default.
• W2036128545 title "Regulation of metallothionein genes in the American oyster (Crassostrea virginica): Ontogeny and differential expression in response to different stressors" @default.
• W2036128545 cites W1495265866 @default.
• W2036128545 cites W1925686649 @default.
• W2036128545 cites W1955702721 @default.
• W2036128545 cites W1964196555 @default.
• W2036128545 cites W1967760014 @default.
• W2036128545 cites W1969597389 @default.
• W2036128545 cites W1977174945 @default.
• W2036128545 cites W1978494589 @default.
• W2036128545 cites W1982846688 @default.
• W2036128545 cites W1984782455 @default.
• W2036128545 cites W1989419577 @default.
• W2036128545 cites W1990390335 @default.
• W2036128545 cites W1999281866 @default.
• W2036128545 cites W2008479587 @default.
• W2036128545 cites W2014191485 @default.
• W2036128545 cites W2021904509 @default.
• W2036128545 cites W2024365580 @default.
• W2036128545 cites W2025562282 @default.
• W2036128545 cites W2026087609 @default.
• W2036128545 cites W2026093245 @default.
• W2036128545 cites W2029358350 @default.
• W2036128545 cites W2030419944 @default.
• W2036128545 cites W2032458072 @default.
• W2036128545 cites W2039369666 @default.
• W2036128545 cites W2039647697 @default.
• W2036128545 cites W2043179564 @default.
• W2036128545 cites W2046887175 @default.
• W2036128545 cites W2051432193 @default.
• W2036128545 cites W2052412186 @default.
• W2036128545 cites W2053070851 @default.
• W2036128545 cites W2055105524 @default.
• W2036128545 cites W2056002855 @default.
• W2036128545 cites W2064286019 @default.
• W2036128545 cites W2073996028 @default.
• W2036128545 cites W2076129474 @default.
• W2036128545 cites W2078884840 @default.
• W2036128545 cites W2083011805 @default.
• W2036128545 cites W2086809297 @default.
• W2036128545 cites W2092762207 @default.
• W2036128545 cites W2103672917 @default.
• W2036128545 cites W2114432201 @default.
• W2036128545 cites W2131510173 @default.
• W2036128545 cites W2133055269 @default.
• W2036128545 cites W2165172658 @default.
• W2036128545 cites W2168945278 @default.
• W2036128545 cites W2173205055 @default.
• W2036128545 cites W2282524445 @default.
• W2036128545 cites W2344392841 @default.
• W2036128545 cites W4252526415 @default.
• W2036128545 doi "https://doi.org/10.1016/j.gene.2006.05.004" @default.
• W2036128545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16846698" @default.
• W2036128545 hasPublicationYear "2006" @default.
• W2036128545 type Work @default.
• W2036128545 sameAs 2036128545 @default.
• W2036128545 citedByCount "53" @default.
• W2036128545 countsByYear W20361285452012 @default.
• W2036128545 countsByYear W20361285452013 @default.
• W2036128545 countsByYear W20361285452014 @default.
• W2036128545 countsByYear W20361285452015 @default.
• W2036128545 countsByYear W20361285452016 @default.
• W2036128545 countsByYear W20361285452017 @default.
• W2036128545 countsByYear W20361285452018 @default.
• W2036128545 countsByYear W20361285452019 @default.
• W2036128545 countsByYear W20361285452020 @default.
• W2036128545 countsByYear W20361285452023 @default.
• W2036128545 crossrefType "journal-article" @default.
• W2036128545 hasAuthorship W2036128545A5007066609 @default.
• W2036128545 hasAuthorship W2036128545A5054791894 @default.
• W2036128545 hasAuthorship W2036128545A5061622282 @default.
• W2036128545 hasAuthorship W2036128545A5065360504 @default.
• W2036128545 hasAuthorship W2036128545A5077490350 @default.
• W2036128545 hasConcept C104317684 @default.
• W2036128545 hasConcept C150194340 @default.
• W2036128545 hasConcept C153911025 @default.
• W2036128545 hasConcept C181199279 @default.
• W2036128545 hasConcept C20719415 @default.
• W2036128545 hasConcept C2776364969 @default.
• W2036128545 hasConcept C2776845067 @default.
• W2036128545 hasConcept C2779201268 @default.
• W2036128545 hasConcept C2781047198 @default.
• W2036128545 hasConcept C505870484 @default.
• W2036128545 hasConcept C515207424 @default.
• W2036128545 hasConcept C53345823 @default.
• W2036128545 hasConcept C54355233 @default.
• W2036128545 hasConcept C55493867 @default.
• W2036128545 hasConcept C86803240 @default.
• W2036128545 hasConceptScore W2036128545C104317684 @default.
• W2036128545 hasConceptScore W2036128545C150194340 @default.

• next