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- W2036135156 abstract "Microspheres with bacampicillin were prepared by the solvent evaporation method using systems methanol, acetone and methyl acetate/liquid paraffin and Eudragit E as polymer. Sieve analysis showed that the particle size of the microspheres follows log - normal distribution with average size of 123, 206 and 300 μm, respectively. Scanning electron microscopy was used to prove that all chosen systems provided the particles of regular spherical shape without aggregationHPLC method was developed for testing drug content, drug stability and dissolution. The results of HPLC analysis showed the exisistence of degradation products of bacampicillin in microspheres prepared by the use of all three solvents. The degree of degradation was the lowest in the case of methyl acetate. The experimental values of dissolution profiles fit well to 0. order and combined 0. and t½ order. The comparison of dissolution profiles of microspheres and bacampicillin itself shows that microspheres produce retard effect and therefore bacampicillin is not expected to be released in saliva after peroral administration of microspheres" @default.
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- W2036135156 date "1989-01-01" @default.
- W2036135156 modified "2023-10-13" @default.
- W2036135156 title "Preparation and Evaluation of Eudragit E Microspheres Containing Bacampicillin" @default.
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- W2036135156 doi "https://doi.org/10.3109/03639048909052532" @default.
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