FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036135280> ?p ?o ?g. }

• W2036135280 endingPage "202" @default.
• W2036135280 startingPage "193" @default.
• W2036135280 abstract "Abstract Sera from 562 patients with IgG, IgA, IgM, IgD or IgE M-components or diffuse hypergammaglobulinemia and from 100 healthy individuals were tested for antibody activity against many or all of 115 different antigens. In low ionic strength buffer ( μ = 0·025), 99 sera (17·8%) had precipitating activity detectable by immunodiffusion against hapten-protein conjugates. DNA, bacterial antigens, carbohydrates, heparin, and phospholipids. Two normal sera gave weak precipitin reactions with nitrophenyl-protein conjugates. In high ionic strength buffer ( μ = 0·2) only 9 of the precipitating sera with M-components, and none of the others, gave strongly positive precipitin reactions with nitrophenyl-protein conjugates, pneumococcal polysaccharides, gums, heparin, cardiolipin, DNA, and nucleoprotein conjugates. M-components from 8 of the 9 precipitating sera, 4 IgG's and 4 IgM's, were purified and their peptic fragments prepared. Two IgG's and two IgM's and their divalent peptic fragments precipitated with DNP- and TNP-BGG when tested by immunodiffusion and quantitative precipitin analysis in high ionic strength buffers. The precipitin curves resembled those observed in conventional antige-antibody systems. They showed weak interaction with various nitrophenyl haptens when tested by hapten inhibition, passive hemagglutination and latex agglutination, modified Farr analyses, equilibrium dialysis, difference spectroscopy, and fluorescence quenching techniques. The low K A values, 10 3 M −1 , as determined by Farr analysis and equilibrium dialysis using DNP- and TNP-haptens were consistent with the weak quantitative precipitin and agglutination results. One IgG and one IgM M-component reacted with low and high mol. wt heparins and heparin derivatives showing typical quantitative precipitin curves, but not with other mucopolysaccharides. The strongest reaction was obtained with high mol. wt heparin. This activity was abolished when the amino-sulphate groups were removed from the heparins. Another IgM M-component had antibody-like activity against cardiolipin. Another IgG M-component reacted with bacterial antigens (pneumococcal SI, III, VIII and X) and related substances (gums karaya and myrrh). The reaction could be inhibited with d -glucuronic acid (10 −3 M ), d -galacturonic acid (10 −2 M ), and l -rhamnose (10 −1 M )." @default.
• W2036135280 created "2016-06-24" @default.
• W2036135280 creator A5024640971 @default.
• W2036135280 creator A5043655838 @default.
• W2036135280 creator A5088971489 @default.
• W2036135280 date "1976-03-01" @default.
• W2036135280 modified "2023-10-03" @default.
• W2036135280 title "Human monoclonal immunoglobulins with antibody-like activity" @default.
• W2036135280 cites W1512149642 @default.
• W2036135280 cites W1518772252 @default.
• W2036135280 cites W1560444542 @default.
• W2036135280 cites W157292085 @default.
• W2036135280 cites W1590058201 @default.
• W2036135280 cites W1609609875 @default.
• W2036135280 cites W1775749144 @default.
• W2036135280 cites W1877845887 @default.
• W2036135280 cites W1966216519 @default.
• W2036135280 cites W1967302742 @default.
• W2036135280 cites W1982713255 @default.
• W2036135280 cites W1988370526 @default.
• W2036135280 cites W1989354561 @default.
• W2036135280 cites W1989673583 @default.
• W2036135280 cites W1993999671 @default.
• W2036135280 cites W2002033924 @default.
• W2036135280 cites W2004880686 @default.
• W2036135280 cites W2011335636 @default.
• W2036135280 cites W2026912546 @default.
• W2036135280 cites W2036107667 @default.
• W2036135280 cites W2053228535 @default.
• W2036135280 cites W2055128901 @default.
• W2036135280 cites W2061965984 @default.
• W2036135280 cites W2067660462 @default.
• W2036135280 cites W2068054596 @default.
• W2036135280 cites W2068850000 @default.
• W2036135280 cites W2085039727 @default.
• W2036135280 cites W2087023130 @default.
• W2036135280 cites W2092679766 @default.
• W2036135280 cites W2101737745 @default.
• W2036135280 cites W2133558312 @default.
• W2036135280 cites W2213211055 @default.
• W2036135280 cites W2232093531 @default.
• W2036135280 cites W2277422674 @default.
• W2036135280 cites W2407198361 @default.
• W2036135280 cites W2977928568 @default.
• W2036135280 cites W82337721 @default.
• W2036135280 cites W90269251 @default.
• W2036135280 doi "https://doi.org/10.1016/0019-2791(76)90215-9" @default.
• W2036135280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/819353" @default.
• W2036135280 hasPublicationYear "1976" @default.
• W2036135280 type Work @default.
• W2036135280 sameAs 2036135280 @default.
• W2036135280 citedByCount "31" @default.
• W2036135280 countsByYear W20361352802013 @default.
• W2036135280 countsByYear W20361352802014 @default.
• W2036135280 crossrefType "journal-article" @default.
• W2036135280 hasAuthorship W2036135280A5024640971 @default.
• W2036135280 hasAuthorship W2036135280A5043655838 @default.
• W2036135280 hasAuthorship W2036135280A5088971489 @default.
• W2036135280 hasConcept C159047783 @default.
• W2036135280 hasConcept C159654299 @default.
• W2036135280 hasConcept C185592680 @default.
• W2036135280 hasConcept C203014093 @default.
• W2036135280 hasConcept C542903549 @default.
• W2036135280 hasConcept C71924100 @default.
• W2036135280 hasConceptScore W2036135280C159047783 @default.
• W2036135280 hasConceptScore W2036135280C159654299 @default.
• W2036135280 hasConceptScore W2036135280C185592680 @default.
• W2036135280 hasConceptScore W2036135280C203014093 @default.
• W2036135280 hasConceptScore W2036135280C542903549 @default.
• W2036135280 hasConceptScore W2036135280C71924100 @default.
• W2036135280 hasIssue "3" @default.
• W2036135280 hasLocation W20361352801 @default.
• W2036135280 hasLocation W20361352802 @default.
• W2036135280 hasOpenAccess W2036135280 @default.
• W2036135280 hasPrimaryLocation W20361352801 @default.
• W2036135280 hasRelatedWork W1843298502 @default.
• W2036135280 hasRelatedWork W1981361863 @default.
• W2036135280 hasRelatedWork W2006538744 @default.
• W2036135280 hasRelatedWork W2038043114 @default.
• W2036135280 hasRelatedWork W2070226647 @default.
• W2036135280 hasRelatedWork W2083879052 @default.
• W2036135280 hasRelatedWork W2130435458 @default.
• W2036135280 hasRelatedWork W2361629369 @default.
• W2036135280 hasRelatedWork W2729974503 @default.
• W2036135280 hasRelatedWork W3203138030 @default.
• W2036135280 hasVolume "13" @default.
• W2036135280 isParatext "false" @default.
• W2036135280 isRetracted "false" @default.
• W2036135280 magId "2036135280" @default.
• W2036135280 workType "article" @default.