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- W2036139444 abstract "Abstract Novel cationic polymers as bile acid sequestrants (BAS) have been considered to be an attractive long‐term therapy for the treatment of hypercholesterolemia. Due to the poor in vivo efficacy of the first generation of BAS like cholestyramine and colestipol, there is a need for discovering new generations of potent BAS. As part of our polymeric drug discovery efforts, we have developed a facile route to prepare functional hydrogels bearing pendant amine and guanidinium groups. The polymeric amines were prepared either by direct polymerization of amine containing monomers or by chemical modification of suitable polymeric precursors. Polymers bearing guanidinium groups were obtained by a polymer analog reaction on crosslinked polymeric amines (primary or secondary) using a readily available guanylating agent in aqueous medium. Incorporation of guanidinium groups to these polymers occurs under mild reaction condition. A numbers of polymer structures with pendant amine and guanidinium groups located a..." @default.
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- W2036139444 date "2004-12-29" @default.
- W2036139444 modified "2023-09-26" @default.
- W2036139444 title "Ammonium and Guanidinium Functionalized Hydrogels as Bile Acid Sequestrants: Synthesis, Characterization, and Biological Properties" @default.
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- W2036139444 doi "https://doi.org/10.1081/ma-120028203" @default.
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