Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036155808> ?p ?o ?g. }
- W2036155808 abstract "The metacestode larva of Echinococcus multilocularis (Cestoda: Taeniidae) develops in the liver of intermediate hosts (typically rodents, or accidentally in humans) as a labyrinth of interconnected cysts that infiltrate the host tissue, causing the disease alveolar echinococcosis. Within the cysts, protoscoleces (the infective stage for the definitive canid host) arise by asexual multiplication. These consist of a scolex similar to that of the adult, invaginated within a small posterior body. Despite the importance of alveolar echinococcosis for human health, relatively little is known about the basic biology, anatomy and development of E. multilocularis larvae, particularly with regard to their nervous system.We describe the existence of a subtegumental nerve net in the metacestode cysts, which is immunoreactive for acetylated tubulin-α and contains small populations of nerve cells that are labeled by antibodies raised against several invertebrate neuropeptides. However, no evidence was found for the existence of cholinergic or serotoninergic elements in the cyst wall. Muscle fibers occur without any specific arrangement in the subtegumental layer, and accumulate during the invaginations of the cyst wall that form brood capsules, where protoscoleces develop. The nervous system of the protoscolex develops independently of that of the metacestode cyst, with an antero-posterior developmental gradient. The combination of antibodies against several nervous system markers resulted in a detailed description of the protoscolex nervous system, which is remarkably complex and already similar to that of the adult worm.We provide evidence for the first time of the existence of a nervous system in the metacestode cyst wall, which is remarkable given the lack of motility of this larval stage, and the lack of serotoninergic and cholinergic elements. We propose that it could function as a neuroendocrine system, derived from the nervous system present in the bladder tissue of other taeniids. The detailed description of the development and anatomy of the protoscolex neuromuscular system is a necessary first step toward the understanding of the developmental mechanisms operating in these peculiar larval stages." @default.
- W2036155808 created "2016-06-24" @default.
- W2036155808 creator A5007656292 @default.
- W2036155808 creator A5031994978 @default.
- W2036155808 creator A5053053716 @default.
- W2036155808 date "2013-05-04" @default.
- W2036155808 modified "2023-10-17" @default.
- W2036155808 title "Anatomy and development of the larval nervous system in Echinococcus multilocularis" @default.
- W2036155808 cites W126874724 @default.
- W2036155808 cites W157460477 @default.
- W2036155808 cites W1597720044 @default.
- W2036155808 cites W1826289561 @default.
- W2036155808 cites W1973682301 @default.
- W2036155808 cites W1973956189 @default.
- W2036155808 cites W1979553110 @default.
- W2036155808 cites W1982154528 @default.
- W2036155808 cites W1984077826 @default.
- W2036155808 cites W1984189425 @default.
- W2036155808 cites W1986138114 @default.
- W2036155808 cites W1987623423 @default.
- W2036155808 cites W1988394934 @default.
- W2036155808 cites W1989664644 @default.
- W2036155808 cites W1993339712 @default.
- W2036155808 cites W1995454234 @default.
- W2036155808 cites W2000508492 @default.
- W2036155808 cites W2006832047 @default.
- W2036155808 cites W2016771776 @default.
- W2036155808 cites W2019263978 @default.
- W2036155808 cites W2023145036 @default.
- W2036155808 cites W2028010079 @default.
- W2036155808 cites W2032653234 @default.
- W2036155808 cites W2032655354 @default.
- W2036155808 cites W2036343428 @default.
- W2036155808 cites W2037198608 @default.
- W2036155808 cites W2058710258 @default.
- W2036155808 cites W2062975676 @default.
- W2036155808 cites W2066057569 @default.
- W2036155808 cites W2067130282 @default.
- W2036155808 cites W2067467422 @default.
- W2036155808 cites W2067832224 @default.
- W2036155808 cites W2068743686 @default.
- W2036155808 cites W2069013587 @default.
- W2036155808 cites W2074120849 @default.
- W2036155808 cites W2076966904 @default.
- W2036155808 cites W2088448945 @default.
- W2036155808 cites W2094473966 @default.
- W2036155808 cites W2095570658 @default.
- W2036155808 cites W2095727844 @default.
- W2036155808 cites W2100694711 @default.
- W2036155808 cites W2106480829 @default.
- W2036155808 cites W2108578585 @default.
- W2036155808 cites W2112388947 @default.
- W2036155808 cites W2112967067 @default.
- W2036155808 cites W2118177287 @default.
- W2036155808 cites W2119125561 @default.
- W2036155808 cites W2127509295 @default.
- W2036155808 cites W2134764248 @default.
- W2036155808 cites W2136550480 @default.
- W2036155808 cites W2142193899 @default.
- W2036155808 cites W2150700233 @default.
- W2036155808 cites W2155398636 @default.
- W2036155808 cites W2170210072 @default.
- W2036155808 cites W2178099580 @default.
- W2036155808 cites W2187895142 @default.
- W2036155808 cites W2213994604 @default.
- W2036155808 cites W2303992804 @default.
- W2036155808 cites W2316310096 @default.
- W2036155808 cites W2319056585 @default.
- W2036155808 cites W2326320000 @default.
- W2036155808 cites W2415714533 @default.
- W2036155808 cites W4211107966 @default.
- W2036155808 cites W4243870019 @default.
- W2036155808 cites W4300842545 @default.
- W2036155808 cites W61229286 @default.
- W2036155808 doi "https://doi.org/10.1186/1742-9994-10-24" @default.
- W2036155808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3658878" @default.
- W2036155808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23642192" @default.
- W2036155808 hasPublicationYear "2013" @default.
- W2036155808 type Work @default.
- W2036155808 sameAs 2036155808 @default.
- W2036155808 citedByCount "43" @default.
- W2036155808 countsByYear W20361558082014 @default.
- W2036155808 countsByYear W20361558082015 @default.
- W2036155808 countsByYear W20361558082016 @default.
- W2036155808 countsByYear W20361558082017 @default.
- W2036155808 countsByYear W20361558082018 @default.
- W2036155808 countsByYear W20361558082019 @default.
- W2036155808 countsByYear W20361558082020 @default.
- W2036155808 countsByYear W20361558082021 @default.
- W2036155808 countsByYear W20361558082022 @default.
- W2036155808 countsByYear W20361558082023 @default.
- W2036155808 crossrefType "journal-article" @default.
- W2036155808 hasAuthorship W2036155808A5007656292 @default.
- W2036155808 hasAuthorship W2036155808A5031994978 @default.
- W2036155808 hasAuthorship W2036155808A5053053716 @default.
- W2036155808 hasBestOaLocation W20361558081 @default.
- W2036155808 hasConcept C105702510 @default.
- W2036155808 hasConcept C126831891 @default.
- W2036155808 hasConcept C142724271 @default.
- W2036155808 hasConcept C165901193 @default.