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• W2036156670 abstract "Complex formation of triamterene and β-cyclodextrin in solution was studied by phase solubility and spectral shift methods. The value of the apparent stability constant, Kc, calculated by these techniques, were 340 and 470 M−1, respectively. Binary systems of triamterene and β-CD were prepared using the dry co-grinding method. Their characterization was performed by Fourier transform infrared spectroscopy and scanning electron microscopy. The main conclusion arising from these studies has been a high interaction between drug and carrier, linked to a clear increase in the amorphous nature of the drug in these systems. Finally, as expected, the 1 min co-ground system presented a notable improvement in its dissolution rate: up to five fold dissolution efficiency over the first 60 min over free drug. This might be attributed to the amorphous state, the increased wettability of the drug and the inclusion complex formation at the liquid state." @default.
• W2036156670 created "2016-06-24" @default.
• W2036156670 creator A5062841971 @default.
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• W2036156670 date "1997-07-30" @default.
• W2036156670 modified "2023-10-16" @default.
• W2036156670 title "Investigation of the triamterene–β-cyclodextrin system prepared by co-grinding" @default.
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• W2036156670 doi "https://doi.org/10.1016/s0378-5173(97)00101-4" @default.
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