Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036157571> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2036157571 endingPage "285" @default.
- W2036157571 startingPage "270" @default.
- W2036157571 abstract "Neurosteroids are able to rapidly control the excitability of the central nervous system, acting as regulators of type A receptors for GABA. Over the last two decades, many authors have confirmed that neurosteroid level alterations occur in psychiatric disorders, including anxiety disorders. More recently, investigators have manipulated neurosteroidogenesis in an effort to correct neuronal excitation and inhibition imbalances, which may lie at the root of neuropsychiatric conditions. In line with this strategy, emerging data have demonstrated that a promising target for therapy of anxiety disorders is the Translocator Protein (TSPO). TSPO is a five transmembrane domain protein (18 kDa) that is expressed predominantly in steroid-synthesizing tissues. At the subcellular level, TSPO is localized at contact sites between the outer and inner mitochondrial membranes and mediates the rate-limiting step of neurosteroidogenesis. Brain concentrations of neurosteroids can be affected by selective TSPO activation. Indeed, TSPO drug ligands are able to stimulate the primary neurosteroid formations that enhance GABAA receptor activity, pregnenolone and allopregnenalone, both in in vitro steroidogenic cells and in vivo animal models. A spectrum of TSPO ligands has been shown to exert anxiolytic actions when administered in rodents. Some TSPO drug ligands could potentially reach clinical development. For example, recent evidence has shown that the selective TSPO ligand, XBD173 (AC-5216, Emapunil), exerts anxiolytic effects not only in animal models, but also in human volunteers. Herein, we review the current literature regarding the central nervous system biology of TSPO, a promising molecular target, in combination with its available ligands." @default.
- W2036157571 created "2016-06-24" @default.
- W2036157571 creator A5058787181 @default.
- W2036157571 creator A5067808979 @default.
- W2036157571 creator A5074047610 @default.
- W2036157571 date "2012-02-01" @default.
- W2036157571 modified "2023-09-27" @default.
- W2036157571 title "Translocator Protein as a Promising Target for Novel Anxiolytics" @default.
- W2036157571 doi "https://doi.org/10.2174/156802612799078720" @default.
- W2036157571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22204481" @default.
- W2036157571 hasPublicationYear "2012" @default.
- W2036157571 type Work @default.
- W2036157571 sameAs 2036157571 @default.
- W2036157571 citedByCount "33" @default.
- W2036157571 countsByYear W20361575712012 @default.
- W2036157571 countsByYear W20361575712013 @default.
- W2036157571 countsByYear W20361575712014 @default.
- W2036157571 countsByYear W20361575712015 @default.
- W2036157571 countsByYear W20361575712016 @default.
- W2036157571 countsByYear W20361575712018 @default.
- W2036157571 countsByYear W20361575712019 @default.
- W2036157571 countsByYear W20361575712020 @default.
- W2036157571 countsByYear W20361575712021 @default.
- W2036157571 countsByYear W20361575712022 @default.
- W2036157571 crossrefType "journal-article" @default.
- W2036157571 hasAuthorship W2036157571A5058787181 @default.
- W2036157571 hasAuthorship W2036157571A5067808979 @default.
- W2036157571 hasAuthorship W2036157571A5074047610 @default.
- W2036157571 hasConcept C126322002 @default.
- W2036157571 hasConcept C168258287 @default.
- W2036157571 hasConcept C169760540 @default.
- W2036157571 hasConcept C170493617 @default.
- W2036157571 hasConcept C185592680 @default.
- W2036157571 hasConcept C2776791281 @default.
- W2036157571 hasConcept C2776914184 @default.
- W2036157571 hasConcept C2777765862 @default.
- W2036157571 hasConcept C2778338918 @default.
- W2036157571 hasConcept C2780193516 @default.
- W2036157571 hasConcept C2780902042 @default.
- W2036157571 hasConcept C2780957381 @default.
- W2036157571 hasConcept C44796713 @default.
- W2036157571 hasConcept C529278444 @default.
- W2036157571 hasConcept C55493867 @default.
- W2036157571 hasConcept C71315377 @default.
- W2036157571 hasConcept C71924100 @default.
- W2036157571 hasConcept C86803240 @default.
- W2036157571 hasConcept C87753298 @default.
- W2036157571 hasConcept C98274493 @default.
- W2036157571 hasConceptScore W2036157571C126322002 @default.
- W2036157571 hasConceptScore W2036157571C168258287 @default.
- W2036157571 hasConceptScore W2036157571C169760540 @default.
- W2036157571 hasConceptScore W2036157571C170493617 @default.
- W2036157571 hasConceptScore W2036157571C185592680 @default.
- W2036157571 hasConceptScore W2036157571C2776791281 @default.
- W2036157571 hasConceptScore W2036157571C2776914184 @default.
- W2036157571 hasConceptScore W2036157571C2777765862 @default.
- W2036157571 hasConceptScore W2036157571C2778338918 @default.
- W2036157571 hasConceptScore W2036157571C2780193516 @default.
- W2036157571 hasConceptScore W2036157571C2780902042 @default.
- W2036157571 hasConceptScore W2036157571C2780957381 @default.
- W2036157571 hasConceptScore W2036157571C44796713 @default.
- W2036157571 hasConceptScore W2036157571C529278444 @default.
- W2036157571 hasConceptScore W2036157571C55493867 @default.
- W2036157571 hasConceptScore W2036157571C71315377 @default.
- W2036157571 hasConceptScore W2036157571C71924100 @default.
- W2036157571 hasConceptScore W2036157571C86803240 @default.
- W2036157571 hasConceptScore W2036157571C87753298 @default.
- W2036157571 hasConceptScore W2036157571C98274493 @default.
- W2036157571 hasIssue "4" @default.
- W2036157571 hasLocation W20361575711 @default.
- W2036157571 hasLocation W20361575712 @default.
- W2036157571 hasOpenAccess W2036157571 @default.
- W2036157571 hasPrimaryLocation W20361575711 @default.
- W2036157571 hasRelatedWork W120647180 @default.
- W2036157571 hasRelatedWork W1969942264 @default.
- W2036157571 hasRelatedWork W2019317626 @default.
- W2036157571 hasRelatedWork W2019564410 @default.
- W2036157571 hasRelatedWork W2036157571 @default.
- W2036157571 hasRelatedWork W2051808624 @default.
- W2036157571 hasRelatedWork W2115707323 @default.
- W2036157571 hasRelatedWork W2131455114 @default.
- W2036157571 hasRelatedWork W2268771058 @default.
- W2036157571 hasRelatedWork W2409360841 @default.
- W2036157571 hasVolume "12" @default.
- W2036157571 isParatext "false" @default.
- W2036157571 isRetracted "false" @default.
- W2036157571 magId "2036157571" @default.
- W2036157571 workType "article" @default.