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• W2036173816 endingPage "9431" @default.
• W2036173816 startingPage "9426" @default.
• W2036173816 abstract "Nuclear export of mRNA is a key transport process in eukaryotic cells. To investigate it, we labeled native mRNP particles in living Chironomus tentans salivary gland cells with fluorescent hrp36, the hnRNP A1 homolog, and the nuclear envelope by fluorescent NTF2. Using light sheet microscopy, we traced single native mRNA particles across the nuclear envelope. The particles were observed to often probe nuclear pore complexes (NPC) at their nuclear face, and in only 25% of the cases yielded actual export. The complete export process took between 65 ms up to several seconds. A rate-limiting step was observed, which could be assigned to the nuclear basket of the pore and might correspond to a repositioning and unfolding of mRNPs before the actual translocation. Analysis of single fluorescent Dbp5 molecules, the RNA helicase essential for mRNA export, revealed that Dbp5 most often approached the cytoplasmic face of the NPC, and exhibited a binding duration of approximately 55 ms. Our results have allowed a refinement of the current models for mRNA export." @default.
• W2036173816 created "2016-06-24" @default.
• W2036173816 creator A5007768668 @default.
• W2036173816 creator A5013697158 @default.
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• W2036173816 date "2012-05-21" @default.
• W2036173816 modified "2023-10-18" @default.
• W2036173816 title "Nuclear export of single native mRNA molecules observed by light sheet fluorescence microscopy" @default.
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• W2036173816 doi "https://doi.org/10.1073/pnas.1201781109" @default.
• W2036173816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3386080" @default.
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• W2036173816 hasPublicationYear "2012" @default.
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