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• W2036175065 abstract "Treatment of macrophages with zymosan, 4β-phorbol 12-myristate 13-acetate (PMA) and fluoride but not with A 23187 or arachidonic acid (ΔAch) leads to a generation of diacylglycerol (acyl2Gro). Formation of inositol phosphates is achieved with zymosan, only. An elevation of intracellular calcium is obtained with zymosan and A 23187 but not with PMA, fluoride or ΔAch. Prior treatment of the cells with phorbol ester for 3 h which has been shown recently to result in a down regulation of protein kinase (PK) C-β but not PKC-δ [Duyster, J., Schwende, H., Fitzke, E., Hidaka H. & Dieter P. (1993) Biochem. J. 292, 203–207] has no effect on the zymosan-induced formation of acyl2Gro or inositol phosphates but inhibits the PMA-induced generation of acyl2Gro. Down regulation of PKC-δ by prior phorbol ester treatment for 24 h augments the zymosan-induced generation of acyl2Gro and inositol phosphates. The acyl2Gro lipase inhibitor RG 80267 inhibits the PMA-induced and fluoride-induced generation of prostaglandin (PG) E2, reduces the zymosan-induced release of PGE2 by 50% but has no effect on PGE2 formation of unstimulated, A 23187 treated or ΔAch-treated cells. Furthermore, RG 80267 enhances accumulation of ΔAch-labeled acyl2Gro in response to zymosan, PMA and fluoride. These data indicate that zymosan activates a phosphatidylinositol 4,5-bisphosphate-specific phospholipase (PL) C, that generation of acyl2Gro by PMA and fluoride occurs via hydrolysis of other phospholipids, that PKC-β is involved in the PMA-induced generation of acyl2Gro and PKC-δ negatively modulates the zymosan-induced activation of PLC and PMA and fluoride induce a liberation of ΔAch from acyl2Gro, A 23187 activates the PLA2 pathway and zymosan stimulates both, the acyl2Gro- and PLA2-pathway." @default.
• W2036175065 created "2016-06-24" @default.
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• W2036175065 date "1993-12-01" @default.
• W2036175065 modified "2023-09-23" @default.
• W2036175065 title "Formation of diacylglycerol, inositol phosphates, arachidonic acid and its metabolites in macrophages" @default.
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• W2036175065 doi "https://doi.org/10.1111/j.1432-1033.1993.tb18430.x" @default.
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