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- W2036183239 abstract "Antigen-specific γδ T cells represent an early innate defense known to play an important role in anti-mycobacterial immunity. We have investigated the immune functions of Vγ9Vδ2 T cells from Broncho-Alveolar lavages (BAC) samples of active TB patients. We observed that BAC Vγ9Vδ2 T cells presented a strong down-modulation of CD3 expression compared with Vγ9Vδ2 T cells from peripheral blood. Furthermore, Vγ9Vδ2 T cells mainly showed a central memory phenotype, expressed high levels of NK inhibitory receptors and TEMRA cells showed low expression of CD16 compared to circulating Vγ9Vδ2 T cells. Interestingly, the ability of BAC Vγ9Vδ2 T cells to respond to antigen stimulation was dramatically reduced, differently from blood counterpart. These observations indicate that γδ T cell functions are specifically impaired in situ by active TB, suggesting that the alveolar ambient during tuberculosis may affect resident γδ T cells in comparison to circulating cells." @default.
- W2036183239 created "2016-06-24" @default.
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- W2036183239 date "2013-04-01" @default.
- W2036183239 modified "2023-10-03" @default.
- W2036183239 title "An abnormal phenotype of lung Vγ9Vδ2 T cells impairs their responsiveness in tuberculosis patients" @default.
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- W2036183239 doi "https://doi.org/10.1016/j.cellimm.2013.05.001" @default.
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