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• W2036187768 abstract "Ischaemia-reperfusion injury (IRI) is of obvious relevance in situations where there is an interruption of blood supply to the gut, as in vascular surgery, or in the construction of free intestinal grafts. It is now appreciated that IRI also underlies the gut dysfunction that occurs in early shock, sepsis, and trauma. The events that occur during IRI are complex. However, recent advances in cellular biology have started to unravel these underlying processes. The aim of this review is to provide an outline of current knowledge on the mechanisms and consequences of IRI. Initially, IRI appears to be mediated by reactive oxygen metabolites and, at a later stage, by the priming and activation of polymorphonuclear neutrophils (PMN). Ischaemia-reperfusion injury can diminish the barrier function of the gut, and can promote an increase in the leakage of molecules (intestinal permeability) or the passage of microbes across the wall of the bowel (bacterial trans-location). Ischaemia-reperfusion injury to the gut can result in the generation of molecules that may also harm distant tissues." @default.
• W2036187768 created "2016-06-24" @default.
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• W2036187768 creator A5079819391 @default.
• W2036187768 date "1998-08-01" @default.
• W2036187768 modified "2023-10-07" @default.
• W2036187768 title "ISCHAEMIA-REPERFUSION INJURY TO THE INTESTINE" @default.
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• W2036187768 doi "https://doi.org/10.1111/j.1445-2197.1998.tb02099.x" @default.
• W2036187768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9715130" @default.
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