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- W2036189156 abstract "The decision of when to begin and what type of osteoporosis treatment to use should be based on the individual need and taking into account other major risks for each individual case: hepatic and renal function, drug allergies, comorbidities, previous treatments, contraindications, secondary effects of the drugs and cost. Osteoporosis, as a chronic disease, requires the use of individualized methods and sequential treatments. In theory, initial treatments would be the use of drugs aimed at the physiopathology of the rapid loss of bone mass during the first years of menopause, which is produced by the increase in secondary bone resorption and the decrease in estrogens. The most appropriate drugs are HRT in symptomatic women and SERMs in asymptomatic ones. The ideal pharmacological SERM profile is an attractive challenge and, after the negative results of the WHI, we would say a necessity. Other possibilities would be HRT for two or three years, and SERMs afterwards (if there are no menopausal symptoms), or the combination of an estrogen with a SERM (TSEC) (if there are any). Later on, there is a period of increased resorption and diminished bone formation, coinciding with more than ten years of menopause and with a greater risk for hip fracture, where drugs such as the bisphosphonates, strontium ranelate or denosumab have shown their effectiveness. Finally, and now in women over 70-75 years of age, there is an important decrease in bone formation (where in cases of very high risk for fracture PTH might be indicated)." @default.
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- W2036189156 date "2012-03-01" @default.
- W2036189156 modified "2023-09-27" @default.
- W2036189156 title "2 STRIPINESS OF MAMMOGRAMS: A NEW TOOL FOR INDIVIDUAL EVALUATION OF HRT EFFECTS ON BREASTS? A PRELIMINARY STUDY" @default.
- W2036189156 doi "https://doi.org/10.1016/s0378-5122(12)70006-3" @default.
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