FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036192008> ?p ?o ?g. }

• W2036192008 endingPage "2268" @default.
• W2036192008 startingPage "2259" @default.
• W2036192008 abstract "Abstract Bone marrow cells (BMCs) could correct some pathologic conditions of the central nervous system (CNS) if these cells would effectively repopulate the brain. One such condition is GM1-gangliosidosis, a neurodegenerative glycosphingolipidosis due to deficiency of lysosomal β-galactosidase (β-gal). In this disease, abnormal build up of GM1-ganglioside in the endoplasmic reticulum of brain cells results in calcium imbalance, induction of an unfolded protein response (UPR), and neuronal apoptosis. These processes are accompanied by the activation/proliferation of microglia and the production of inflammatory cytokines. Here we demonstrate that local neuroinflammation promotes the selective activation of chemokines, such as stromal-cell-derived factor 1 (SDF-1), macrophage inflammatory protein 1-α (MIP-1α), and MIP-1β, which chemoattract genetically modified BMCs into the CNS. Mice that underwent bone marrow transplantation showed increased β-gal activity in different brain regions and reduced lysosomal storage. Decreased production of chemokines and effectors of the UPR as well as restoration of neurologic functions accompanied this phenotypic reversion. Our results suggest that β-gal-expressing bone marrow (BM)-derived cells selectively migrate to the CNS under a gradient of chemokines and become a source of correcting enzyme to deficient neurons. Thus, a disease condition such as GM1-gangliosidosis, which is characterized by neurodegeneration and neuroinflammation, may influence the response of the CNS to ex vivo gene therapy." @default.
• W2036192008 created "2016-06-24" @default.
• W2036192008 creator A5025259805 @default.
• W2036192008 creator A5074222588 @default.
• W2036192008 creator A5075421946 @default.
• W2036192008 creator A5089240105 @default.
• W2036192008 date "2005-10-01" @default.
• W2036192008 modified "2023-10-17" @default.
• W2036192008 title "Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of GM1-gangliosidosis mice corrects neuronal pathology" @default.
• W2036192008 cites W1482688899 @default.
• W2036192008 cites W1585492421 @default.
• W2036192008 cites W1901938190 @default.
• W2036192008 cites W1963873817 @default.
• W2036192008 cites W1966613691 @default.
• W2036192008 cites W1966839779 @default.
• W2036192008 cites W1968690802 @default.
• W2036192008 cites W1974960001 @default.
• W2036192008 cites W1975521881 @default.
• W2036192008 cites W1979231367 @default.
• W2036192008 cites W1998592507 @default.
• W2036192008 cites W1998597651 @default.
• W2036192008 cites W2004641904 @default.
• W2036192008 cites W2011644481 @default.
• W2036192008 cites W2013435769 @default.
• W2036192008 cites W2015816621 @default.
• W2036192008 cites W2020632854 @default.
• W2036192008 cites W2022448315 @default.
• W2036192008 cites W2027927113 @default.
• W2036192008 cites W2028762442 @default.
• W2036192008 cites W2030697317 @default.
• W2036192008 cites W2031215335 @default.
• W2036192008 cites W2036165697 @default.
• W2036192008 cites W2039347757 @default.
• W2036192008 cites W2043139614 @default.
• W2036192008 cites W2045175180 @default.
• W2036192008 cites W2045281561 @default.
• W2036192008 cites W2050753211 @default.
• W2036192008 cites W2053315646 @default.
• W2036192008 cites W2063970717 @default.
• W2036192008 cites W2077676332 @default.
• W2036192008 cites W2080678920 @default.
• W2036192008 cites W2080911273 @default.
• W2036192008 cites W2083172100 @default.
• W2036192008 cites W2093453769 @default.
• W2036192008 cites W2096385871 @default.
• W2036192008 cites W2099675490 @default.
• W2036192008 cites W2103369019 @default.
• W2036192008 cites W2122810522 @default.
• W2036192008 cites W2123635819 @default.
• W2036192008 cites W2128258658 @default.
• W2036192008 cites W2141080862 @default.
• W2036192008 cites W2145655362 @default.
• W2036192008 cites W2160272188 @default.
• W2036192008 cites W2292370633 @default.
• W2036192008 cites W2306784901 @default.
• W2036192008 cites W2410676956 @default.
• W2036192008 cites W2415623010 @default.
• W2036192008 cites W4211264883 @default.
• W2036192008 cites W4234282571 @default.
• W2036192008 cites W4242443907 @default.
• W2036192008 cites W99374810 @default.
• W2036192008 doi "https://doi.org/10.1182/blood-2005-03-1189" @default.
• W2036192008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895262" @default.
• W2036192008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15941905" @default.
• W2036192008 hasPublicationYear "2005" @default.
• W2036192008 type Work @default.
• W2036192008 sameAs 2036192008 @default.
• W2036192008 citedByCount "76" @default.
• W2036192008 countsByYear W20361920082012 @default.
• W2036192008 countsByYear W20361920082013 @default.
• W2036192008 countsByYear W20361920082014 @default.
• W2036192008 countsByYear W20361920082015 @default.
• W2036192008 countsByYear W20361920082016 @default.
• W2036192008 countsByYear W20361920082017 @default.
• W2036192008 countsByYear W20361920082019 @default.
• W2036192008 countsByYear W20361920082020 @default.
• W2036192008 countsByYear W20361920082021 @default.
• W2036192008 countsByYear W20361920082022 @default.
• W2036192008 countsByYear W20361920082023 @default.
• W2036192008 crossrefType "journal-article" @default.
• W2036192008 hasAuthorship W2036192008A5025259805 @default.
• W2036192008 hasAuthorship W2036192008A5074222588 @default.
• W2036192008 hasAuthorship W2036192008A5075421946 @default.
• W2036192008 hasAuthorship W2036192008A5089240105 @default.
• W2036192008 hasBestOaLocation W20361920081 @default.
• W2036192008 hasConcept C13373296 @default.
• W2036192008 hasConcept C142724271 @default.
• W2036192008 hasConcept C16930146 @default.
• W2036192008 hasConcept C203014093 @default.
• W2036192008 hasConcept C2776914184 @default.
• W2036192008 hasConcept C2776925932 @default.
• W2036192008 hasConcept C2779134260 @default.
• W2036192008 hasConcept C2779830541 @default.
• W2036192008 hasConcept C2780007613 @default.
• W2036192008 hasConcept C502942594 @default.
• W2036192008 hasConcept C71924100 @default.
• W2036192008 hasConcept C86803240 @default.
• W2036192008 hasConcept C87753298 @default.

• next