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• W2036199141 abstract "Glucose-stimulated insulin secretion [GSIS] involves a sequence of metabolic events leading to small G-protein [e.g., Rac1]-mediated cytoskeletal remodeling to promote granule mobilization toward the plasma membrane for fusion and release of insulin. Existing evidence supports a positive modulatory role for Rac1 in GSIS. Specific regulatory factors of Rac1 function, including the guanine nucleotide exchange factors [e.g., Tiam1] have also been identified and studied in the islet. Inhibition of Tiam1/Rac1 signaling axis attenuates GSIS suggesting its pivotal role in insulin secretion. In addition to its positive [i.e., friendly] roles in GSIS, Rac1 also plays non-friendly role[s] in the islet function. For example, it up-regulates the intracellular reactive oxygen species [ROS] levels via activation of phagocyte-like NADPH oxidase [Nox]. Despite the emerging evidence that a tonic increase in intracellular ROS is necessary for GSIS, experimental evidence also suggests that chronic exposure of β-cells to high glucose, palmitate or cytokines results in the onset of oxidative stress leading to reduction in mitochondrial membrane potential, cytosolic accumulation of cytochrome C and activation of caspase-3 leading to β-cell apoptosis. Pharmacological and molecular biological inhibition of Rac1 activation affords partial protection against Nox-induced oxidative stress and mitochondrial dysfunction induced by elevated glucose, lipids or cytokines. Herein, we overview the existing evidence to suggest positive as well as negative modulatory roles of Rac1 in islet function. Potential avenues for future research including development of inhibitors to halt the Rac1-Nox activation and generation of oxidative stress leading to the metabolic dysfunction of the β-cell are discussed." @default.
• W2036199141 created "2016-06-24" @default.
• W2036199141 creator A5081710987 @default.
• W2036199141 date "2011-04-01" @default.
• W2036199141 modified "2023-09-24" @default.
• W2036199141 title "Friendly, and not so friendly, roles of Rac1 in islet β-cell function: Lessons learnt from pharmacological and molecular biological approaches" @default.
• W2036199141 cites W1533372919 @default.
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• W2036199141 cites W1572992923 @default.
• W2036199141 cites W1586099293 @default.
• W2036199141 cites W1587506196 @default.
• W2036199141 cites W1624592313 @default.
• W2036199141 cites W1963487532 @default.
• W2036199141 cites W1964980219 @default.
• W2036199141 cites W1966068360 @default.
• W2036199141 cites W1966351307 @default.
• W2036199141 cites W1968832284 @default.
• W2036199141 cites W1976108411 @default.
• W2036199141 cites W1976339688 @default.
• W2036199141 cites W1983859356 @default.
• W2036199141 cites W1984678726 @default.
• W2036199141 cites W1985413317 @default.
• W2036199141 cites W1992716613 @default.
• W2036199141 cites W1996097063 @default.
• W2036199141 cites W1996107157 @default.
• W2036199141 cites W2001743136 @default.
• W2036199141 cites W2014578258 @default.
• W2036199141 cites W2015695338 @default.
• W2036199141 cites W2017701987 @default.
• W2036199141 cites W2019656882 @default.
• W2036199141 cites W2021786313 @default.
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• W2036199141 cites W2025960625 @default.
• W2036199141 cites W2038977244 @default.
• W2036199141 cites W2041963174 @default.
• W2036199141 cites W2046692619 @default.
• W2036199141 cites W2046960792 @default.
• W2036199141 cites W2053448161 @default.
• W2036199141 cites W2058677692 @default.
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• W2036199141 cites W2063575573 @default.
• W2036199141 cites W2063778796 @default.
• W2036199141 cites W2077564898 @default.
• W2036199141 cites W2081375253 @default.
• W2036199141 cites W2081561931 @default.
• W2036199141 cites W2082515526 @default.
• W2036199141 cites W2084102889 @default.
• W2036199141 cites W2084699108 @default.
• W2036199141 cites W2088952174 @default.
• W2036199141 cites W2089887078 @default.
• W2036199141 cites W2093761649 @default.
• W2036199141 cites W2099142346 @default.
• W2036199141 cites W2102364870 @default.
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• W2036199141 cites W2106913297 @default.
• W2036199141 cites W2109069544 @default.
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• W2036199141 cites W2113574003 @default.
• W2036199141 cites W2114648756 @default.
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• W2036199141 cites W2119491918 @default.
• W2036199141 cites W2126032145 @default.
• W2036199141 cites W2126355299 @default.
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• W2036199141 cites W2134523442 @default.
• W2036199141 cites W2146631359 @default.
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• W2036199141 cites W2153237239 @default.
• W2036199141 cites W2153866356 @default.
• W2036199141 cites W2164509237 @default.
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• W2036199141 cites W2167718876 @default.
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• W2036199141 doi "https://doi.org/10.1016/j.bcp.2011.01.013" @default.
• W2036199141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3073707" @default.
• W2036199141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21300027" @default.
• W2036199141 hasPublicationYear "2011" @default.
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