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- W2036202072 abstract "The racemic mixture propranolol (RS-(±)-, and theS-(−)- andR-(+)-) isomers of propranolol have been shown to induce bronchial hyperresponsiveness in the guinea-pig unrelated toβ-adrenoreceptor occupancy, that is attentuated by vagal section and mediated via the generation of 5-lipoxygenase metabolites of arachidonic acid. We have investigated the role of sensory nerves in propranolol-induced bronchial hyperresponsiveness in guinea-pigs. Airways responsiveness to acetylcholine, bradykinin and bombesin was determined before and 10 min after intravenous infusion withRS-(±)-,S-(−)- andR-(+)-propranolol (1 mg/kg) in vehicle and capsaicin-treated guinea-pigs. Propranolol (1 mg/kg, iv) significantly augmented the bronchoconstrictor response to acetylcholine, bradykinin and bombesin (P<0.001), an effect that was observed forRS-(±)-,S-(−)- andR-(+)-propranolol. In capsaicin-treated animals, the increased airways responsiveness to acetylcholine following intravenous infusion ofS-(−)-propranolol was significantly inhibited. Capsaicin treatment tended to reduce the increase in airways responsiveness to bradykinin following infusion withR-(+)-propranolol, but was only significant for the highest dose used. Similarly, capsaicin treatment had no effect on the ability ofRS-(±)-,S-(−)- andR-(+)-propranolol to enhance the bronchoconstrictor response to bombesin. Our results suggest that propranolol-induced bronchial hyperresponsiveness to certain spasmogens is in part mediated by the action of capsaicin-sensitive nerves." @default.
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- W2036202072 title "The Role of Sensory Nerves in Propranolol-Induced Bronchial Hyperresponsiveness in the Guinea-pig" @default.
- W2036202072 doi "https://doi.org/10.1006/pupt.1999.0167" @default.
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