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- W2036208429 abstract "Introduction: Flt3 (FMS-like tyrosine kinase 3) has been presented as a target for novel anti-leukemic drugs because Flt3 mutations have been observed in acute myeloid leukemia (AML) cells. Due to both the poor efficacy and high toxicity of current standard AML therapies, there is an unmet need for new, improved therapies. Flt3 inhibitors have great potential to address this with mutated Flt3. Areas covered: This paper provides a comprehensive review of the Flt3 inhibitor patents currently available. Information from original research articles in peer-reviewed journals and current clinical developments from several resources is also described. Expert opinion: Our understanding of Flt3 inhibitors has been increased by findings from recent preclinical and clinical trials. Some Flt3 inhibitors show good efficacy in AML patients, but relapse and resistance to these inhibitors are still unavoidable. To address these problems, structurally diverse inhibitors, which exhibit inhibitory activities against both wild type and mutated Flt3, should be explored." @default.
- W2036208429 created "2016-06-24" @default.
- W2036208429 creator A5039379192 @default.
- W2036208429 creator A5054648435 @default.
- W2036208429 creator A5089817503 @default.
- W2036208429 date "2011-02-17" @default.
- W2036208429 modified "2023-09-24" @default.
- W2036208429 title "FMS-like tyrosine kinase 3 inhibitors: a patent review" @default.
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- W2036208429 doi "https://doi.org/10.1517/13543776.2011.560115" @default.
- W2036208429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21323612" @default.
- W2036208429 hasPublicationYear "2011" @default.
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