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• W2036222753 abstract "We have investigated the contribution of the interferon (IFN)-α/β system, IFN-γ and nitric oxide to recovery from infection with Murray Valley encephalitis virus, using a mouse model for flaviviral encephalitis where a small dose of virus was administered to 6-week-old wild-type and gene knockout animals by the intravenous route. We show that a defect in the IFN-α/β responses results in uncontrolled extraneural virus growth, rapid virus entry into the brain and 100 % mortality. In contrast, mice deficient in IFN-γ or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus." @default.
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• W2036222753 date "2003-03-01" @default.
• W2036222753 modified "2023-09-26" @default.
• W2036222753 title "Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus" @default.
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• W2036222753 doi "https://doi.org/10.1099/vir.0.18654-0" @default.
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