FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036238945> ?p ?o ?g. }

• W2036238945 endingPage "530.e3" @default.
• W2036238945 startingPage "521" @default.
• W2036238945 abstract "Aberrant activation of the signal transducer and activator of transcription (Stat)3 and overexpression of polo-like kinase (PLK)1 each have been associated with cancer pathogenesis. The mechanisms and significance of dysregulation of Stat3 and PLK1 in carcinogenesis and cancer progression are unclear. We investigated the relationship between Stat3 and PLK1 and the effects of their dysregulation in esophageal squamous cell carcinoma (ESCC) cells.We used immunoblot, quantitative reverse-transcription polymerase chain reaction, immunochemistry, chromatin immunoprecipitation, mobility shift, and reporter assays to investigate the relationship between Stat3 and PLK1. We used colony formation, fluorescence-activated cell sorting, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling, and xenograft tumor assays to determine the effects of increased activation of Stat3 and PLK1 in proliferation and survival of ESCC cells.Stat3 directly activated transcription of PLK1 in esophageal cancer cells and mouse embryonic fibroblast cell NIH3T3. PLK1 then potentiated the expression of Stat3; β-catenin was involved in PLK1-dependent transcriptional activation of Stat3. This mutual regulation between Stat3 and PLK1 was required for proliferation of esophageal cancer cells and resistance to apoptosis in culture and as tumor xenografts in mice. Furthermore, phosphorylation of Stat3 and overexpression of PLK1 were correlated in a subset of ESCC.Stat3 and PLK1 control each other's transcription in a positive feedback loop that contributes to the development of ESCC. Increased activity of Stat3 and overexpression of PLK1 promote survival and proliferation of ESCC cells in culture and in mice." @default.
• W2036238945 created "2016-06-24" @default.
• W2036238945 creator A5004474677 @default.
• W2036238945 creator A5004686722 @default.
• W2036238945 creator A5020700981 @default.
• W2036238945 creator A5022303526 @default.
• W2036238945 creator A5028509208 @default.
• W2036238945 creator A5031817044 @default.
• W2036238945 creator A5048378786 @default.
• W2036238945 creator A5051502959 @default.
• W2036238945 creator A5055110183 @default.
• W2036238945 creator A5063077523 @default.
• W2036238945 creator A5063643036 @default.
• W2036238945 creator A5066036281 @default.
• W2036238945 creator A5088287990 @default.
• W2036238945 creator A5090413393 @default.
• W2036238945 date "2012-03-01" @default.
• W2036238945 modified "2023-10-06" @default.
• W2036238945 title "Reciprocal Activation Between PLK1 and Stat3 Contributes to Survival and Proliferation of Esophageal Cancer Cells" @default.
• W2036238945 cites W1495457417 @default.
• W2036238945 cites W1495655723 @default.
• W2036238945 cites W1548640328 @default.
• W2036238945 cites W1973908775 @default.
• W2036238945 cites W1975776530 @default.
• W2036238945 cites W2006401070 @default.
• W2036238945 cites W2007807048 @default.
• W2036238945 cites W2029108033 @default.
• W2036238945 cites W2037874673 @default.
• W2036238945 cites W2040825881 @default.
• W2036238945 cites W2041204531 @default.
• W2036238945 cites W2042210471 @default.
• W2036238945 cites W2043188148 @default.
• W2036238945 cites W2044992780 @default.
• W2036238945 cites W2053272914 @default.
• W2036238945 cites W2074356752 @default.
• W2036238945 cites W2076183717 @default.
• W2036238945 cites W2077381664 @default.
• W2036238945 cites W2083802827 @default.
• W2036238945 cites W2086715846 @default.
• W2036238945 cites W2114135705 @default.
• W2036238945 cites W2116628300 @default.
• W2036238945 cites W2121840229 @default.
• W2036238945 cites W2127019295 @default.
• W2036238945 cites W2131711802 @default.
• W2036238945 cites W2132047377 @default.
• W2036238945 cites W2138408725 @default.
• W2036238945 cites W2783142245 @default.
• W2036238945 cites W4246727707 @default.
• W2036238945 cites W4249713142 @default.
• W2036238945 doi "https://doi.org/10.1053/j.gastro.2011.11.023" @default.
• W2036238945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22108192" @default.
• W2036238945 hasPublicationYear "2012" @default.
• W2036238945 type Work @default.
• W2036238945 sameAs 2036238945 @default.
• W2036238945 citedByCount "81" @default.
• W2036238945 countsByYear W20362389452012 @default.
• W2036238945 countsByYear W20362389452013 @default.
• W2036238945 countsByYear W20362389452014 @default.
• W2036238945 countsByYear W20362389452015 @default.
• W2036238945 countsByYear W20362389452016 @default.
• W2036238945 countsByYear W20362389452017 @default.
• W2036238945 countsByYear W20362389452018 @default.
• W2036238945 countsByYear W20362389452019 @default.
• W2036238945 countsByYear W20362389452020 @default.
• W2036238945 countsByYear W20362389452021 @default.
• W2036238945 countsByYear W20362389452022 @default.
• W2036238945 countsByYear W20362389452023 @default.
• W2036238945 crossrefType "journal-article" @default.
• W2036238945 hasAuthorship W2036238945A5004474677 @default.
• W2036238945 hasAuthorship W2036238945A5004686722 @default.
• W2036238945 hasAuthorship W2036238945A5020700981 @default.
• W2036238945 hasAuthorship W2036238945A5022303526 @default.
• W2036238945 hasAuthorship W2036238945A5028509208 @default.
• W2036238945 hasAuthorship W2036238945A5031817044 @default.
• W2036238945 hasAuthorship W2036238945A5048378786 @default.
• W2036238945 hasAuthorship W2036238945A5051502959 @default.
• W2036238945 hasAuthorship W2036238945A5055110183 @default.
• W2036238945 hasAuthorship W2036238945A5063077523 @default.
• W2036238945 hasAuthorship W2036238945A5063643036 @default.
• W2036238945 hasAuthorship W2036238945A5066036281 @default.
• W2036238945 hasAuthorship W2036238945A5088287990 @default.
• W2036238945 hasAuthorship W2036238945A5090413393 @default.
• W2036238945 hasConcept C101762097 @default.
• W2036238945 hasConcept C104317684 @default.
• W2036238945 hasConcept C121608353 @default.
• W2036238945 hasConcept C134320426 @default.
• W2036238945 hasConcept C146276462 @default.
• W2036238945 hasConcept C150194340 @default.
• W2036238945 hasConcept C153911025 @default.
• W2036238945 hasConcept C171958077 @default.
• W2036238945 hasConcept C190283241 @default.
• W2036238945 hasConcept C2778923194 @default.
• W2036238945 hasConcept C29537977 @default.
• W2036238945 hasConcept C502942594 @default.
• W2036238945 hasConcept C54355233 @default.
• W2036238945 hasConcept C55493867 @default.
• W2036238945 hasConcept C555283112 @default.
• W2036238945 hasConcept C62112901 @default.

• next