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• W2036243080 abstract "A new 32-mer 2',5'-oligoribonucleotide of 1-methyl-6-thioinosinic acid (10) has been synthesized. The design of this unique oligoribonucleotide is based on the reported HIV inhibitory activities of both 2',5'-oligonucleotides and the 3',5'-oligoribonucleotides containing the 1-methyl-6-mercaptopurine base. Tm and CD studies of 10 revealed that it has no organized secondary structure, presumably due to the rigidity of the molecule. The synthesized oligomer, 10, showed a potent inhibitory effect on HIV-1RF and significantly inhibited HIV-1 reverse transcriptase." @default.
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• W2036243080 date "2004-12-31" @default.
• W2036243080 modified "2023-09-27" @default.
• W2036243080 title "An Unusual “Senseless” 2′,5′‐Oligoribonucleotide With Potent Anti‐Hiv Activity" @default.
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• W2036243080 doi "https://doi.org/10.1081/ncn-120030713" @default.
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