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- W2036245737 abstract "Quinolone antimicrobials have been associated with arthropathy following oral administration for 7 days to immature animals. Therefore, the oral dosage form contains label restrictions for use in children. This study was designed to evaluate the toxicity potential of ciprofloxacin ophthalmic solution (Ciloxan) on the developing bones and joints of immature dogs. Three groups of four dogs, two/sex/group, 8 weeks old, were treated with 0.3% or 0.75% ciprofloxacin ophthalmic solution four times daily for 5 weeks. An additional group of young dogs was utilized as an untreated control group. No treatment-related pharmacotoxicity, ocular, serum chemistry, hematologic, or histopathologic changes were observed. Plasma analyses demonstrated no detectable levels of ciprofloxacin following 5 weeks of treatment. These data indicate a low potential for ocular or systemic toxicity for ciprofloxacin ophthalmic solution, including no adverse effects on bone growth or the articular surfaces of young animals." @default.
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- W2036245737 date "1993-01-01" @default.
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- W2036245737 title "Systemic and Ocular Safety of Ciprofloxacin Ophthalmic Solution (Ciloxan) in Immature Animals" @default.
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- W2036245737 doi "https://doi.org/10.3109/15569529309050144" @default.
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