Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036246856> ?p ?o ?g. }
- W2036246856 endingPage "253" @default.
- W2036246856 startingPage "253" @default.
- W2036246856 abstract "Targeted approaches in the treatment of osteoporosis: differential mechanism of action of denosumab and clinical utility Loredana Cavalli, Maria Luisa BrandiUnit of Mineral and Bone Metabolism Diseases, Department of Internal Medicine, Traumatologic Orthopedic Center, Florence, ItalyAbstract: Denosumab is a breakthrough biological drug approved by the Food and Drug Administration and European Medicines Agency for the treatment of osteoporosis in 2010. It is a fully human monoclonal antireceptor activator of nuclear factor kappa-B ligand antibody, which inhibits the activity of osteoclasts, resulting in an antiresorptive effect with a significant increase in bone mineral density. The FREEDOM (Fracture Reduction Evaluation of Denosumab in Osteoporosis every 6 Months) trial, comparing denosumab with no treatment in 7868 women with postmenopausal osteoporosis, showed an important reduction of fracture risk at hip, vertebral, and nonvertebral sites in the treated group, while no statistically significant difference in the incidence of adverse events was detected between denosumab and placebo groups. The specific action of denosumab directed against a key regulator of osteoclasts makes it a valuable tool in preventing the occurrence of skeletal events caused by bone destruction in patients with advanced malignancies. The drug was approved for postmenopausal osteoporosis in women at increased risk of fracture and for the treatment of bone loss associated with androgen deprivation therapy in men with prostate cancer.Keywords: osteoporosis, denosumab, targeted therapy, BMD, antibody, RANK-L" @default.
- W2036246856 created "2016-06-24" @default.
- W2036246856 creator A5023433703 @default.
- W2036246856 creator A5055069129 @default.
- W2036246856 date "2012-06-01" @default.
- W2036246856 modified "2023-10-03" @default.
- W2036246856 title "Targeted approaches in the treatment of osteoporosis: differential mechanism of action of denosumab and clinical utility" @default.
- W2036246856 cites W15103804 @default.
- W2036246856 cites W1534645474 @default.
- W2036246856 cites W164503306 @default.
- W2036246856 cites W1650001464 @default.
- W2036246856 cites W1964755289 @default.
- W2036246856 cites W1966064911 @default.
- W2036246856 cites W1966390646 @default.
- W2036246856 cites W1971610058 @default.
- W2036246856 cites W1975805439 @default.
- W2036246856 cites W1976389084 @default.
- W2036246856 cites W1977598461 @default.
- W2036246856 cites W1978611346 @default.
- W2036246856 cites W1979253120 @default.
- W2036246856 cites W1981266896 @default.
- W2036246856 cites W1982310023 @default.
- W2036246856 cites W1983090947 @default.
- W2036246856 cites W1988541434 @default.
- W2036246856 cites W1988801456 @default.
- W2036246856 cites W1989848145 @default.
- W2036246856 cites W1989860636 @default.
- W2036246856 cites W1992804470 @default.
- W2036246856 cites W1993035292 @default.
- W2036246856 cites W2000647744 @default.
- W2036246856 cites W2001468998 @default.
- W2036246856 cites W2002699743 @default.
- W2036246856 cites W2004140351 @default.
- W2036246856 cites W2009756491 @default.
- W2036246856 cites W2015721758 @default.
- W2036246856 cites W2020909365 @default.
- W2036246856 cites W2021623450 @default.
- W2036246856 cites W2024098071 @default.
- W2036246856 cites W2029064643 @default.
- W2036246856 cites W2036282225 @default.
- W2036246856 cites W2036368043 @default.
- W2036246856 cites W2042450573 @default.
- W2036246856 cites W2042827704 @default.
- W2036246856 cites W2043166269 @default.
- W2036246856 cites W2048183034 @default.
- W2036246856 cites W2048299560 @default.
- W2036246856 cites W2048346627 @default.
- W2036246856 cites W2048964656 @default.
- W2036246856 cites W2052946642 @default.
- W2036246856 cites W2053261087 @default.
- W2036246856 cites W2057332307 @default.
- W2036246856 cites W2061790220 @default.
- W2036246856 cites W2064947472 @default.
- W2036246856 cites W2065242899 @default.
- W2036246856 cites W2066591855 @default.
- W2036246856 cites W2069499812 @default.
- W2036246856 cites W2071702951 @default.
- W2036246856 cites W2079640720 @default.
- W2036246856 cites W2084865918 @default.
- W2036246856 cites W2087578607 @default.
- W2036246856 cites W2088924780 @default.
- W2036246856 cites W2090714871 @default.
- W2036246856 cites W2092721372 @default.
- W2036246856 cites W2092985976 @default.
- W2036246856 cites W2093057350 @default.
- W2036246856 cites W2093252878 @default.
- W2036246856 cites W2099054178 @default.
- W2036246856 cites W2106766464 @default.
- W2036246856 cites W2108027777 @default.
- W2036246856 cites W2111261443 @default.
- W2036246856 cites W2114935509 @default.
- W2036246856 cites W2116605720 @default.
- W2036246856 cites W2118914286 @default.
- W2036246856 cites W2119062112 @default.
- W2036246856 cites W2120433336 @default.
- W2036246856 cites W2120516305 @default.
- W2036246856 cites W2128843508 @default.
- W2036246856 cites W2132608007 @default.
- W2036246856 cites W2132973962 @default.
- W2036246856 cites W2133551420 @default.
- W2036246856 cites W2137868736 @default.
- W2036246856 cites W2137911215 @default.
- W2036246856 cites W2139996507 @default.
- W2036246856 cites W2141306851 @default.
- W2036246856 cites W2146217561 @default.
- W2036246856 cites W2149775776 @default.
- W2036246856 cites W2152065905 @default.
- W2036246856 cites W2152578289 @default.
- W2036246856 cites W2153122488 @default.
- W2036246856 cites W2157193896 @default.
- W2036246856 cites W2158952295 @default.
- W2036246856 cites W2160005424 @default.
- W2036246856 cites W2161546266 @default.
- W2036246856 cites W2162150486 @default.
- W2036246856 cites W2163058169 @default.
- W2036246856 cites W2167886526 @default.
- W2036246856 cites W2168451480 @default.
- W2036246856 cites W2168890875 @default.