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• W2036248885 abstract "STAT92E is an essential transcription factor in <i>Drosophila melanogaster</i> for the development of several organs and the immune system. The JAK/STAT pathway employs different evolutionary conserved regulatory mechanisms to control biological processes. Numerous transcription factors in both mammals and invertebrates have been shown to be either activated or inhibited by a covalent modification with a small ubiquitin-like modifier (Sumo). Here, we show that <i>Drosophila</i> STAT92E is modified by Sumo at a single lysine residue 187 in S2 cells. Mutation of Lys187 increases the transcriptional activity of STAT92E, thus suggesting that sumoylation of STAT92E has a repressive role in the regulation of the JAK/STAT pathway in<i> Drosophila melanogaster.</i>" @default.
• W2036248885 created "2016-06-24" @default.
• W2036248885 creator A5013709767 @default.
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• W2036248885 creator A5054414026 @default.
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• W2036248885 date "2010-01-01" @default.
• W2036248885 modified "2023-10-03" @default.
• W2036248885 title "Sumoylation of Drosophila Transcription Factor STAT92E" @default.
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• W2036248885 doi "https://doi.org/10.1159/000318676" @default.
• W2036248885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20616536" @default.
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