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- W2036252124 abstract "Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FLThe ADAMs (A Disintegrin and Metalloproteinase) comprise a family of multidomain transmembrane and secreted proteins involved in cytokine and growth factor release, proteolysis and cell adhesion. Multiple family members have been shown to play a role in cancer formation and disease progression. Decreased ADAM23 expression has been demonstrated in human breast, colon, gastric, head and neck, brain and pancreatic cancers and is believed to be associated with a more malignant or metastatic phenotype. Substantially more than 1 million cases of non-melanoma skin cancer (NMSC) occur annually in the United States according to the American Cancer Society. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the two major types of NMSC and most are related to chronic sun exposure. We have demonstrated by microarray analysis that ADAM23 expression is decreased in human keratinocytes chronically irradiated with a solar-simulated light source. Using a human SCC skin carcinogenesis model, we have demonstrated that decreased ADAM23 expression correlates with disease progression. Preliminary immunohistochemical analysis of human SCC samples also demonstrates decreased ADAM23 expression. We believe that ADAM23 may serve as a biomarker of human skin SCC disease progression. This may be important for earlier detection and for the possible development of targeted therapy that may serve as an alternative to potentially disfiguring surgical treatment.This work was supported in part by PHS grant CA27502 and CA23074 from the National Cancer Institute and the National Institutes of Health. It was also supported in part by start-up funds supplied by the Department of Medicine at the University of Arizona School of Medicine.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4190. doi:10.1158/1538-7445.AM2011-4190" @default.
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- W2036252124 date "2011-04-15" @default.
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- W2036252124 title "Abstract 4190: ADAM23: Biomarker for nonmelanoma skin cancer disease progression" @default.
- W2036252124 doi "https://doi.org/10.1158/1538-7445.am2011-4190" @default.
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