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- W2036267066 abstract "Abstract The study presented here was undertaken to assess the time-associated changes in disposition of bupivacaine during continuous interpleural infusion. Seven female patients undergoing open cholecystectomy received a continuous interpleural infusion of bupivacaine (25 mg/hr) for 72 hours after an initial bolus dose of 50 mg. Blood concentrations of bupivacaine (determined by gas chromatography) at defined time intervals were then modelled using a two-compartment model. Peak blood concentrations of 1.68 μg/ml (range 0.97 to 2.49 μg/ml) were measured in all patients at 48 hours and then declined significantly over the subsequent 24 hours. This was paralleled by a significant apparent increase in clearance. Therefore, we could not confirm the widely postulated accumulation of bupivacaine over long-term infusion; on the contrary we found non-stationary kinetics with decreasing concentrations and increasing clearance over 72 hours, explicable either by changes in hepatic clearance or alteration in protein binding." @default.
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- W2036267066 date "1997-12-01" @default.
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- W2036267066 title "Non-stationary pharmacokinetics of bupivacaine during continuous interpleural infusion" @default.
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- W2036267066 doi "https://doi.org/10.1016/s1366-0071(97)80030-7" @default.
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