FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036275464> ?p ?o ?g. }

• W2036275464 endingPage "1953" @default.
• W2036275464 startingPage "1945" @default.
• W2036275464 abstract "The diffusion of small nutrients in the intervertebral human disc was examined using a finite element model.To investigate nutrient transport into the disc using a numerical approach.The intervertebral disc is the largest avascular tissue in the body. Nutrients necessary for cellular survival diffuse from the blood supply around the disc margins to the cells. Limited analytical studies have been performed and compared with measurements. However, the studies have only considered supply through the center of the nucleus and have only examined single solutes. A more sophisticated model is required to investigate the solute supply.An axisymmetric finite element model has been created to study the transport of three solutes, i.e., oxygen, glucose, and lactate, using nonlinear consumption-concentration and production-concentration rates. For each of them, data for the consumption/production rate, diffusivity, and concentration in the blood were taken from experimental measurements and used in the model. The effect of varying disc height, exchange area with the blood supply, solute consumption rates, and diffusivities was investigated.The model predicted that concentrations of oxygen and glucose, which are consumed by cells, fell towards the disc center. Concentration levels decreased with a decrease in fractional exchange area and diffusivity, or with an increase in disc height and consumption rate. In contrast, the concentration of lactate, produced by the cells, was highest in the center and fell towards the disc-blood vessel interface. The absolute values of concentrations were in agreement with available measurements in vivo and those computed by few available analytical models, indicating the reliability of the finite element simulations.Finite element methods can be used to predict concentration gradients of solutes throughout the disc in relation to changes in disc and endplate morphology, disc properties, and cellular activities. This study provides a foundation for investigating the effect of load-induced changes or effects of changes in cellular metabolism on disc nutritional supply." @default.
• W2036275464 created "2016-06-24" @default.
• W2036275464 creator A5026362389 @default.
• W2036275464 creator A5057538162 @default.
• W2036275464 creator A5074917286 @default.
• W2036275464 date "2003-09-01" @default.
• W2036275464 modified "2023-10-01" @default.
• W2036275464 title "Finite Element Study of Nutrient Diffusion in the Human Intervertebral Disc" @default.
• W2036275464 cites W154044508 @default.
• W2036275464 cites W1988303352 @default.
• W2036275464 cites W1991677480 @default.
• W2036275464 cites W1999075857 @default.
• W2036275464 cites W1999138373 @default.
• W2036275464 cites W2028053908 @default.
• W2036275464 cites W2057188704 @default.
• W2036275464 cites W2060600598 @default.
• W2036275464 cites W2066108134 @default.
• W2036275464 cites W2069346876 @default.
• W2036275464 cites W2075767828 @default.
• W2036275464 cites W2079900591 @default.
• W2036275464 cites W2082875594 @default.
• W2036275464 cites W2084617311 @default.
• W2036275464 cites W2094166936 @default.
• W2036275464 cites W2109513249 @default.
• W2036275464 cites W2146499626 @default.
• W2036275464 cites W2147237892 @default.
• W2036275464 cites W2153969760 @default.
• W2036275464 cites W2332850050 @default.
• W2036275464 cites W2338817155 @default.
• W2036275464 cites W2474088718 @default.
• W2036275464 doi "https://doi.org/10.1097/01.brs.0000087210.93541.23" @default.
• W2036275464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12973139" @default.
• W2036275464 hasPublicationYear "2003" @default.
• W2036275464 type Work @default.
• W2036275464 sameAs 2036275464 @default.
• W2036275464 citedByCount "99" @default.
• W2036275464 countsByYear W20362754642012 @default.
• W2036275464 countsByYear W20362754642013 @default.
• W2036275464 countsByYear W20362754642014 @default.
• W2036275464 countsByYear W20362754642015 @default.
• W2036275464 countsByYear W20362754642016 @default.
• W2036275464 countsByYear W20362754642017 @default.
• W2036275464 countsByYear W20362754642018 @default.
• W2036275464 countsByYear W20362754642019 @default.
• W2036275464 countsByYear W20362754642020 @default.
• W2036275464 countsByYear W20362754642021 @default.
• W2036275464 countsByYear W20362754642022 @default.
• W2036275464 countsByYear W20362754642023 @default.
• W2036275464 crossrefType "journal-article" @default.
• W2036275464 hasAuthorship W2036275464A5026362389 @default.
• W2036275464 hasAuthorship W2036275464A5057538162 @default.
• W2036275464 hasAuthorship W2036275464A5074917286 @default.
• W2036275464 hasConcept C105702510 @default.
• W2036275464 hasConcept C121332964 @default.
• W2036275464 hasConcept C135628077 @default.
• W2036275464 hasConcept C136229726 @default.
• W2036275464 hasConcept C2777755357 @default.
• W2036275464 hasConcept C3018239782 @default.
• W2036275464 hasConcept C37668627 @default.
• W2036275464 hasConcept C44575665 @default.
• W2036275464 hasConcept C57879066 @default.
• W2036275464 hasConcept C69357855 @default.
• W2036275464 hasConcept C71924100 @default.
• W2036275464 hasConcept C97355855 @default.
• W2036275464 hasConceptScore W2036275464C105702510 @default.
• W2036275464 hasConceptScore W2036275464C121332964 @default.
• W2036275464 hasConceptScore W2036275464C135628077 @default.
• W2036275464 hasConceptScore W2036275464C136229726 @default.
• W2036275464 hasConceptScore W2036275464C2777755357 @default.
• W2036275464 hasConceptScore W2036275464C3018239782 @default.
• W2036275464 hasConceptScore W2036275464C37668627 @default.
• W2036275464 hasConceptScore W2036275464C44575665 @default.
• W2036275464 hasConceptScore W2036275464C57879066 @default.
• W2036275464 hasConceptScore W2036275464C69357855 @default.
• W2036275464 hasConceptScore W2036275464C71924100 @default.
• W2036275464 hasConceptScore W2036275464C97355855 @default.
• W2036275464 hasIssue "17" @default.
• W2036275464 hasLocation W20362754641 @default.
• W2036275464 hasLocation W20362754642 @default.
• W2036275464 hasOpenAccess W2036275464 @default.
• W2036275464 hasPrimaryLocation W20362754641 @default.
• W2036275464 hasRelatedWork W1967151028 @default.
• W2036275464 hasRelatedWork W1974234315 @default.
• W2036275464 hasRelatedWork W1991325299 @default.
• W2036275464 hasRelatedWork W2006955533 @default.
• W2036275464 hasRelatedWork W2081847682 @default.
• W2036275464 hasRelatedWork W2158580444 @default.
• W2036275464 hasRelatedWork W2366799757 @default.
• W2036275464 hasRelatedWork W2411091114 @default.
• W2036275464 hasRelatedWork W2621170731 @default.
• W2036275464 hasRelatedWork W97853105 @default.
• W2036275464 hasVolume "28" @default.
• W2036275464 isParatext "false" @default.
• W2036275464 isRetracted "false" @default.
• W2036275464 magId "2036275464" @default.
• W2036275464 workType "article" @default.