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• W2036275701 startingPage "449" @default.
• W2036275701 abstract "Myosin heavy chain (MHC) isoform composition was determined in 2264 single skeletal muscle fibers from vastus lateralis muscle of a group (n = 12) of very old subjects (average age, 88 years). The number of fibers containing only MHC I, IIA, or IIX was 19.9%, 27.2%, and 0.3%, respectively. Surprisingly, 28.5% of the fibers displayed coexpression of both MHC I and IIA, a phenotype that is present in younger adults in very small percentages. Among these fibers coexpressing MHC I and IIA, the majority had a dominant expression of MHC I. Additionally, a small number of fibers coexpressing MHC I and IIX without any MHC IIA, and fibers coexpressing all three isoforms were observed. Altogether, 52.6% of all fibers examined in these very old subjects coexpressed two or three MHC isoforms. The present study provides evidence that advanced age leads to a significant elevation of skeletal muscle fibers displaying coexpression of two MHC isoforms and that a separation into slow and fast fibers in very old individuals may therefore be somewhat misleading. The clinical significance of the elevated number of fibers coexpressing MHC I and IIA is uncertain. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 449–454, 1999." @default.
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• W2036275701 date "1999-04-01" @default.
• W2036275701 modified "2023-10-16" @default.
• W2036275701 title "Increase in the degree of coexpression of myosin heavy chain isoforms in skeletal muscle fibers of the very old" @default.
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• W2036275701 doi "https://doi.org/10.1002/(sici)1097-4598(199904)22:4<449::aid-mus4>3.0.co;2-2" @default.
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