Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036281623> ?p ?o ?g. }
- W2036281623 endingPage "1016" @default.
- W2036281623 startingPage "1002" @default.
- W2036281623 abstract "The peroxisome proliferator-activated receptors (PPARs) and the retinoid X receptors (RXRs) are ligand-activated transcription factors that coordinately regulate gene expression. This PPAR-RXR transcriptional complex plays a critical role in energy balance, including triglyceride metabolism, fatty acid handling and storage, and glucose homeostasis: processes whose dysregulation characterize obesity, diabetes, and atherosclerosis. PPARs and RXRs are also involved directly in inflammatory and vascular responses in endothelial and vascular smooth muscle cells. New insights into fundamental aspects of PPAR and RXR biology, and their actions in the vasculature, continue to appear. Although RXRs are obligate heterodimeric partners for PPAR action, the part that RXRs, and their endogenous retinoid mediators, exert in the vessel wall is less well understood. Biological insights into PPAR-RXRs may help inform interpretation of clinical trials with synthetic PPAR agonists and prospects for future PPAR therapeutics. Importantly, the extensive data establishing a key role for PPARs and RXRs in energy balance, inflammation, and vascular biology stands separately from the clinical experience with any given synthetic PPAR agonist. Both the basic science data and the clinical experience with PPAR agonists identify the need to better understand these important transcriptional regulators." @default.
- W2036281623 created "2016-06-24" @default.
- W2036281623 creator A5051351787 @default.
- W2036281623 date "2011-04-15" @default.
- W2036281623 modified "2023-09-27" @default.
- W2036281623 title "The PPAR-RXR Transcriptional Complex in the Vasculature" @default.
- W2036281623 cites W1494611500 @default.
- W2036281623 cites W1520429340 @default.
- W2036281623 cites W1548641817 @default.
- W2036281623 cites W1583180850 @default.
- W2036281623 cites W1824116550 @default.
- W2036281623 cites W1884680894 @default.
- W2036281623 cites W1963772784 @default.
- W2036281623 cites W1964499513 @default.
- W2036281623 cites W1964646513 @default.
- W2036281623 cites W1967209079 @default.
- W2036281623 cites W1967491514 @default.
- W2036281623 cites W1968319041 @default.
- W2036281623 cites W1968659767 @default.
- W2036281623 cites W1970164658 @default.
- W2036281623 cites W1976416423 @default.
- W2036281623 cites W1976486537 @default.
- W2036281623 cites W1977666051 @default.
- W2036281623 cites W1978800134 @default.
- W2036281623 cites W1979030077 @default.
- W2036281623 cites W1981963822 @default.
- W2036281623 cites W1985516506 @default.
- W2036281623 cites W1986069274 @default.
- W2036281623 cites W1987273813 @default.
- W2036281623 cites W1987601141 @default.
- W2036281623 cites W1988036748 @default.
- W2036281623 cites W1988123744 @default.
- W2036281623 cites W1990905123 @default.
- W2036281623 cites W1992574349 @default.
- W2036281623 cites W1993728889 @default.
- W2036281623 cites W1993820363 @default.
- W2036281623 cites W1996038870 @default.
- W2036281623 cites W1997416444 @default.
- W2036281623 cites W1997608114 @default.
- W2036281623 cites W2002762124 @default.
- W2036281623 cites W2003247644 @default.
- W2036281623 cites W2007381747 @default.
- W2036281623 cites W2007582789 @default.
- W2036281623 cites W2014277844 @default.
- W2036281623 cites W2016099444 @default.
- W2036281623 cites W2017671227 @default.
- W2036281623 cites W2020852287 @default.
- W2036281623 cites W2021969219 @default.
- W2036281623 cites W2022448511 @default.
- W2036281623 cites W2023239847 @default.
- W2036281623 cites W2023459898 @default.
- W2036281623 cites W2027258546 @default.
- W2036281623 cites W2028497702 @default.
- W2036281623 cites W2029522112 @default.
- W2036281623 cites W2029567365 @default.
- W2036281623 cites W2029931635 @default.
- W2036281623 cites W2030897216 @default.
- W2036281623 cites W2030921297 @default.
- W2036281623 cites W2035313241 @default.
- W2036281623 cites W2037917220 @default.
- W2036281623 cites W2038409034 @default.
- W2036281623 cites W2044136517 @default.
- W2036281623 cites W2045425403 @default.
- W2036281623 cites W2045744255 @default.
- W2036281623 cites W2047852384 @default.
- W2036281623 cites W2047905476 @default.
- W2036281623 cites W2048732925 @default.
- W2036281623 cites W2056961945 @default.
- W2036281623 cites W2057120998 @default.
- W2036281623 cites W2059906195 @default.
- W2036281623 cites W2063018677 @default.
- W2036281623 cites W2063404995 @default.
- W2036281623 cites W2063831952 @default.
- W2036281623 cites W2063956641 @default.
- W2036281623 cites W2064579441 @default.
- W2036281623 cites W2064617441 @default.
- W2036281623 cites W2068231503 @default.
- W2036281623 cites W2070283156 @default.
- W2036281623 cites W2081275316 @default.
- W2036281623 cites W2081578244 @default.
- W2036281623 cites W2083007126 @default.
- W2036281623 cites W2084974435 @default.
- W2036281623 cites W2086789099 @default.
- W2036281623 cites W2087351233 @default.
- W2036281623 cites W2089756004 @default.
- W2036281623 cites W2090570558 @default.
- W2036281623 cites W2090857330 @default.
- W2036281623 cites W2091007186 @default.
- W2036281623 cites W2091466360 @default.
- W2036281623 cites W2091544680 @default.
- W2036281623 cites W2092001735 @default.
- W2036281623 cites W2092136583 @default.
- W2036281623 cites W2092318458 @default.
- W2036281623 cites W2096146827 @default.
- W2036281623 cites W2096210401 @default.
- W2036281623 cites W2097105383 @default.
- W2036281623 cites W2097762754 @default.
- W2036281623 cites W2098108405 @default.