Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036289383> ?p ?o ?g. }
- W2036289383 endingPage "17382" @default.
- W2036289383 startingPage "17375" @default.
- W2036289383 abstract "Human blood plasma and serum pose significant challenges to implanted devices because of highly unfavorable nonspecific protein adsorption on the surface. In this work, we introduce an improved two-step method to immobilize initiator thiols on a gold substrate for the surface-initiated atom-transfer radical polymerization (SI-ATRP) of hydroxypropyl methacrylate (HPMA). We investigate protein adsorption from a single-protein solution, diluted (10%) and undiluted (100%) human blood plasma, and serum on the poly(HPMA) brushes with different film thicknesses using surface plasmon resonance (SPR) sensors. SPR results show a correlation between antifouling properties and film thickness; that is, the poly(HPMA) brushes exhibit high protein resistance at medium film thicknesses of ∼25−40 nm (e.g. <0.3 ng/cm2 for single-protein adsorption and 10% human blood plasma and serum, ∼24.5 ng/cm2 for 100% human serum, and ∼52.8 ng/cm2 for 100% human plasma at a thickness of ∼29 nm). With an optimal film thickness and surface roughness, the poly(HPMA) brush also demonstrates its high resistance to fibroblast adhesion. This work provides an alternative surface polymerization approach to preparing effective antifouling poly(HPMA) materials for potential applications in blood-contacting medical devices." @default.
- W2036289383 created "2016-06-24" @default.
- W2036289383 creator A5024000881 @default.
- W2036289383 creator A5062023507 @default.
- W2036289383 creator A5084580172 @default.
- W2036289383 date "2010-10-13" @default.
- W2036289383 modified "2023-09-30" @default.
- W2036289383 title "Achieving Highly Effective Nonfouling Performance for Surface-Grafted Poly(HPMA) via Atom-Transfer Radical Polymerization" @default.
- W2036289383 cites W1610965833 @default.
- W2036289383 cites W1967754359 @default.
- W2036289383 cites W1968965037 @default.
- W2036289383 cites W1975410474 @default.
- W2036289383 cites W1978161967 @default.
- W2036289383 cites W1995353935 @default.
- W2036289383 cites W1995690804 @default.
- W2036289383 cites W2002787964 @default.
- W2036289383 cites W2004709778 @default.
- W2036289383 cites W2006757507 @default.
- W2036289383 cites W2012806326 @default.
- W2036289383 cites W2018267895 @default.
- W2036289383 cites W2018605111 @default.
- W2036289383 cites W2021060402 @default.
- W2036289383 cites W2022007544 @default.
- W2036289383 cites W2023962452 @default.
- W2036289383 cites W2031328542 @default.
- W2036289383 cites W2031376643 @default.
- W2036289383 cites W2032368146 @default.
- W2036289383 cites W2032683682 @default.
- W2036289383 cites W2034098926 @default.
- W2036289383 cites W2034520377 @default.
- W2036289383 cites W2036659872 @default.
- W2036289383 cites W2037997664 @default.
- W2036289383 cites W2042132347 @default.
- W2036289383 cites W2049059816 @default.
- W2036289383 cites W2050488145 @default.
- W2036289383 cites W2054100802 @default.
- W2036289383 cites W2058374592 @default.
- W2036289383 cites W2064636572 @default.
- W2036289383 cites W2064909929 @default.
- W2036289383 cites W2066654154 @default.
- W2036289383 cites W2068809896 @default.
- W2036289383 cites W2069870790 @default.
- W2036289383 cites W2074469051 @default.
- W2036289383 cites W2074880818 @default.
- W2036289383 cites W2078739630 @default.
- W2036289383 cites W2124444208 @default.
- W2036289383 cites W2131082021 @default.
- W2036289383 cites W2169880564 @default.
- W2036289383 doi "https://doi.org/10.1021/la103382j" @default.
- W2036289383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20942427" @default.
- W2036289383 hasPublicationYear "2010" @default.
- W2036289383 type Work @default.
- W2036289383 sameAs 2036289383 @default.
- W2036289383 citedByCount "88" @default.
- W2036289383 countsByYear W20362893832012 @default.
- W2036289383 countsByYear W20362893832013 @default.
- W2036289383 countsByYear W20362893832014 @default.
- W2036289383 countsByYear W20362893832015 @default.
- W2036289383 countsByYear W20362893832016 @default.
- W2036289383 countsByYear W20362893832017 @default.
- W2036289383 countsByYear W20362893832018 @default.
- W2036289383 countsByYear W20362893832019 @default.
- W2036289383 countsByYear W20362893832020 @default.
- W2036289383 countsByYear W20362893832021 @default.
- W2036289383 countsByYear W20362893832022 @default.
- W2036289383 countsByYear W20362893832023 @default.
- W2036289383 crossrefType "journal-article" @default.
- W2036289383 hasAuthorship W2036289383A5024000881 @default.
- W2036289383 hasAuthorship W2036289383A5062023507 @default.
- W2036289383 hasAuthorship W2036289383A5084580172 @default.
- W2036289383 hasConcept C106847996 @default.
- W2036289383 hasConcept C127413603 @default.
- W2036289383 hasConcept C132050475 @default.
- W2036289383 hasConcept C150394285 @default.
- W2036289383 hasConcept C150539798 @default.
- W2036289383 hasConcept C155672457 @default.
- W2036289383 hasConcept C159985019 @default.
- W2036289383 hasConcept C171250308 @default.
- W2036289383 hasConcept C178790620 @default.
- W2036289383 hasConcept C185592680 @default.
- W2036289383 hasConcept C188027245 @default.
- W2036289383 hasConcept C192562407 @default.
- W2036289383 hasConcept C41625074 @default.
- W2036289383 hasConcept C42360764 @default.
- W2036289383 hasConcept C44228677 @default.
- W2036289383 hasConcept C521977710 @default.
- W2036289383 hasConcept C55493867 @default.
- W2036289383 hasConcept C6047279 @default.
- W2036289383 hasConcept C84416704 @default.
- W2036289383 hasConcept C88001094 @default.
- W2036289383 hasConceptScore W2036289383C106847996 @default.
- W2036289383 hasConceptScore W2036289383C127413603 @default.
- W2036289383 hasConceptScore W2036289383C132050475 @default.
- W2036289383 hasConceptScore W2036289383C150394285 @default.
- W2036289383 hasConceptScore W2036289383C150539798 @default.
- W2036289383 hasConceptScore W2036289383C155672457 @default.
- W2036289383 hasConceptScore W2036289383C159985019 @default.
- W2036289383 hasConceptScore W2036289383C171250308 @default.