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- W2036290147 abstract "O ne of the ethical pillars of medical treatment has always been to “do no harm.” Treating patients with diabetes medications, however, carries a significant risk of inflicting harm and injury by causing hypoglycemia. Were it not for this potential adverse reaction, diabetes treatment would be considerably easier for both patients and providers.Such treatments frequently involve augmenting insulin effects directly (injected insulin) or indirectly (increasing insulin release from the pancreatic β-cells, increasing insulin sensitivity, and/or inhibiting hepatic glucose production). Whenever glucose homeostasis is altered, hypoglycemia is always a potential side effect to therapy and, in fact, is one of the most common adverse reactions in diabetes treatment.It is important, therefore, to be able to identify, treat, and also avoid the hypoglycemic complications of diabetes therapy. Such complications may even be life-threatening and resistant to initial therapy. Therefore, physicians who prescribe potent diabetes medications such as insulin must be able to identify the causes of such adverse reactions and arrest such complications before they progress.Hypoglycemia is in many ways the Achilles heel of diabetes treatment. Medical authors have astutely noted that hypoglycemia is the “limiting factor” in the treatment of diabetes.1–3 Reduction of glucose levels in patients with either type 1 or type 2 diabetes has been shown to decrease the risks of kidney, nerve, and retinal injury. Lower glucose levels are also associated with a reduction in cardiovascular disease in patients with type 1 diabetes. Were it not for the development of hypoglycemia, all patients with diabetes could conceivably control their diabetes with ease using high doses of oral medications or insulin.Such is not the case, however. Treatment of diabetes, especially intensive treatment, carries a significant risk of lowering blood glucose levels excessively and causing hypoglycemia. Severe hypoglycemia is usually considered to be …" @default.
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- W2036290147 date "2011-01-01" @default.
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- W2036290147 title "The Diabetes Treatment Trap: Hypoglycemia" @default.
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- W2036290147 doi "https://doi.org/10.2337/diaclin.29.1.36" @default.
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