FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036294223> ?p ?o ?g. }

• W2036294223 endingPage "71" @default.
• W2036294223 startingPage "65" @default.
• W2036294223 abstract "Gram-negative sepsis is a potentially fatal clinical syndrome characterized by a proinflammatory response (tumor necrosis factor-α) to bacterial (endo)toxins and gut barrier function loss. Recently, we found that high-fat enteral nutrition protects against late bacterial translocation in a model of hemorrhagic shock in rats. However, the basis for this protection is unknown. We hypothesized that the observed protection is the result of an early inhibition of endotoxin and the subsequent inflammatory response resulting in a preserved gut barrier function. Sprague–Dawley rats were divided into a group that was starved overnight (HS-S), fed with a low-fat enteral diet (HS-LF) or fed wih a high-fat enteral diet (HS-HF), and subsequently subjected to a nonlethal hemorrhagic shock. Ninety minutes after hemorrhage, arterial endotoxin significantly decreased in HS-HF rats (4.0 ± 0.6 pg/mL) compared with HS-LF rats (10.7 ± 0.9 pg/mL, P = 0.002) and HS-S rats (15.2 ± 2.2 pg/mL P = 0.001). Interestingly, arterial tumor necrosis factor-α was also decreased in HS-HF rats (17.9 ± 10.4 pg/mL) compared with HS-LF (83.5 ± 16.7 pg/mL, P < 0.01) and HS-S rats (180.9 ± 67.9 pg/mL, P < 0.02). Loss of tight junction structure (ZO-1) observed in ileum and colon of control hemorrhagic shock rats was prevented in HS-HF rats. In parallel, intestinal barrier function was preserved in HS-HF rats, evidenced by a reduced permeability to horseradish peroxidase (P < 0.05), less bacterial invasion, and a 10-fold reduction of bacterial translocation early after hemorrhagic shock. This report describes a new strategy to nutritionally prevent endotoxemia, the subsequent inflammatory response and gut barrier failure following hemorrhagic shock. High-fat enteral nutrition requires further evaluation as an intervention to prevent a potentially fatal systemic inflammatory response in patients at risk for sepsis." @default.
• W2036294223 created "2016-06-24" @default.
• W2036294223 creator A5010280330 @default.
• W2036294223 creator A5014668607 @default.
• W2036294223 creator A5019509998 @default.
• W2036294223 creator A5030001421 @default.
• W2036294223 creator A5046227757 @default.
• W2036294223 creator A5053269718 @default.
• W2036294223 creator A5081308630 @default.
• W2036294223 date "2004-01-01" @default.
• W2036294223 modified "2023-10-18" @default.
• W2036294223 title "Pretreatment With High-Fat Enteral Nutrition Reduces Endotoxin and Tumor Necrosis Factor-?? and Preserves Gut Barrier Function Early After Hemorrhagic Shock" @default.
• W2036294223 cites W1555519553 @default.
• W2036294223 cites W1701869895 @default.
• W2036294223 cites W1968713831 @default.
• W2036294223 cites W1995044262 @default.
• W2036294223 cites W2002050974 @default.
• W2036294223 cites W2013636295 @default.
• W2036294223 cites W2045767332 @default.
• W2036294223 cites W2053972162 @default.
• W2036294223 cites W2055041145 @default.
• W2036294223 cites W2061207287 @default.
• W2036294223 cites W2062122576 @default.
• W2036294223 cites W2065013470 @default.
• W2036294223 cites W2071702504 @default.
• W2036294223 cites W2073753647 @default.
• W2036294223 cites W2075047806 @default.
• W2036294223 cites W2075921226 @default.
• W2036294223 cites W2076243684 @default.
• W2036294223 cites W2078633249 @default.
• W2036294223 cites W2079555223 @default.
• W2036294223 cites W2081371688 @default.
• W2036294223 cites W2086776938 @default.
• W2036294223 cites W2093620974 @default.
• W2036294223 cites W2134215776 @default.
• W2036294223 cites W2135772628 @default.
• W2036294223 cites W2141062801 @default.
• W2036294223 cites W2156015271 @default.
• W2036294223 cites W2158092179 @default.
• W2036294223 cites W2159420204 @default.
• W2036294223 cites W2273939376 @default.
• W2036294223 cites W2416889861 @default.
• W2036294223 doi "https://doi.org/10.1097/01.shk.0000101671.49265.cf" @default.
• W2036294223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14676686" @default.
• W2036294223 hasPublicationYear "2004" @default.
• W2036294223 type Work @default.
• W2036294223 sameAs 2036294223 @default.
• W2036294223 citedByCount "80" @default.
• W2036294223 countsByYear W20362942232012 @default.
• W2036294223 countsByYear W20362942232013 @default.
• W2036294223 countsByYear W20362942232014 @default.
• W2036294223 countsByYear W20362942232015 @default.
• W2036294223 countsByYear W20362942232016 @default.
• W2036294223 countsByYear W20362942232017 @default.
• W2036294223 countsByYear W20362942232018 @default.
• W2036294223 countsByYear W20362942232020 @default.
• W2036294223 countsByYear W20362942232021 @default.
• W2036294223 crossrefType "journal-article" @default.
• W2036294223 hasAuthorship W2036294223A5010280330 @default.
• W2036294223 hasAuthorship W2036294223A5014668607 @default.
• W2036294223 hasAuthorship W2036294223A5019509998 @default.
• W2036294223 hasAuthorship W2036294223A5030001421 @default.
• W2036294223 hasAuthorship W2036294223A5046227757 @default.
• W2036294223 hasAuthorship W2036294223A5053269718 @default.
• W2036294223 hasAuthorship W2036294223A5081308630 @default.
• W2036294223 hasBestOaLocation W20362942231 @default.
• W2036294223 hasConcept C126322002 @default.
• W2036294223 hasConcept C134018914 @default.
• W2036294223 hasConcept C164027704 @default.
• W2036294223 hasConcept C177779419 @default.
• W2036294223 hasConcept C17991360 @default.
• W2036294223 hasConcept C185592680 @default.
• W2036294223 hasConcept C2776914184 @default.
• W2036294223 hasConcept C2778384902 @default.
• W2036294223 hasConcept C2781300812 @default.
• W2036294223 hasConcept C44315111 @default.
• W2036294223 hasConcept C51911345 @default.
• W2036294223 hasConcept C55493867 @default.
• W2036294223 hasConcept C71924100 @default.
• W2036294223 hasConcept C78722104 @default.
• W2036294223 hasConcept C86803240 @default.
• W2036294223 hasConcept C95444343 @default.
• W2036294223 hasConceptScore W2036294223C126322002 @default.
• W2036294223 hasConceptScore W2036294223C134018914 @default.
• W2036294223 hasConceptScore W2036294223C164027704 @default.
• W2036294223 hasConceptScore W2036294223C177779419 @default.
• W2036294223 hasConceptScore W2036294223C17991360 @default.
• W2036294223 hasConceptScore W2036294223C185592680 @default.
• W2036294223 hasConceptScore W2036294223C2776914184 @default.
• W2036294223 hasConceptScore W2036294223C2778384902 @default.
• W2036294223 hasConceptScore W2036294223C2781300812 @default.
• W2036294223 hasConceptScore W2036294223C44315111 @default.
• W2036294223 hasConceptScore W2036294223C51911345 @default.
• W2036294223 hasConceptScore W2036294223C55493867 @default.
• W2036294223 hasConceptScore W2036294223C71924100 @default.
• W2036294223 hasConceptScore W2036294223C78722104 @default.
• W2036294223 hasConceptScore W2036294223C86803240 @default.
• W2036294223 hasConceptScore W2036294223C95444343 @default.

• next